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Innovative nanotransistor for easy measurement of electrolyte concentration in blood

(Nanowerk News) Testing the blood of patients that doctors believe may be suffering from an electrolyte imbalance is usually a major effort because various selective tests have to be performed. Electrolytes are certain nutrients or chemicals in the body that carry out a number of important functions, such as regulating the heartbeat. A disruption of the electrolyte balance can be dangerous.
Researchers working in the field of chemistry are examining the chemical compounds of electrolytes, which are partly split into ions and conduct electrical currents.
Remco Hartkamp, tenure-track lecturer of computational chemical physics at the Department of Process & Energy, developed a new method, together with researchers from the Centre National de la Recherche Scientifique (CNRS) in France and the NTT Basic Research Laboratories in Japan, that will make it easier to measure the concentration of different electrolytes in the body using a nanotransistor.
Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor
The results of the research were published this month in the Nature Materials("Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor").

Research Summary

The researchers presented what they called a 0D ion-selective field-effect transistor (ISFET), with a sensor of just 25 nm - much smaller than the conventional nanowire ISFETs. Compared to currently available devices, the 0D-ISFET showed a qualitatively different response to changes in pH and a much higher sensitivity to the presence of electrolytes, making it possible to sense electrolytes that are present in very small concentrations.
Combining the experiments with molecular dynamics simulations and site-binding theory, new insight was acquired.
Specifically, a theoretical approach to the trends found in the experimental measurements suggested an additive, rather than competitive, effect of mixed electrolytes on the electric potential at the solid-liquid interface. Furthermore, simulations suggested that the high sensitivity of the 0D-ISFET, especially with respect to divalent ions, may be caused by an excess of cations adsorbing onto the charged solid surface. Such overscreening is ascribed to a combination of electrostatic correlations and ion-specific adsorption.
Source: TU Delft
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