Just add heat to open this tiny box: Nanocubes automatically connect, disassemble at different temperatures

(Nanowerk News) Researchers have designed two types of nano-sized building blocks that can automatically connect into cubes and scramble back into individual components based on the temperature of their environment (Nature Communications, "Temperature-controlled repeatable scrambling and induced-sorting of building blocks between cubic assemblies"). This accomplishment is another step towards chemical systems that more realistically mimic life.
Schematic of the energy shifts between different versions of a self-assembling nanocube
Schematic of the energy shifts between different versions of a self-assembling nanocube. Researchers at the University of Tokyo have designed two types of nanocubes whose building blocks, hexaphenylbenzene derivative molecules (represented as red and blue), can automatically combine and scramble repeatedly based on the temperature of their environment. This ability comes from the different temperature stabilities of the two cubes. (© Nature Communications)
“Imagine mixing two liquids together, like ink and water. They will automatically do the simple chemical process of dispersing until they are perfectly mixed,” said Professor Shuichi Hiraoka of the University of Tokyo Department of Basic Science.
“However, there’s no chemical process to automatically separate water and ink - you need to boil the water into a gas to separate it from the ink,” he added.
The new building blocks designed by Hiroka's team can connect or scramble themselves automatically because of the different temperature stabilities of the cubes that they form.
The two types of building blocks are nearly identical and are shaped like snowflakes. Researchers color them red or blue in schematic diagrams. A cube assembled from red blocks is stable below 130 degrees Celsius (266 degrees Fahrenheit), while a cube assembled from blue blocks is stable only below 65 degrees Celsius (149 degrees Fahrenheit).
When kept apart, the building blocks connect into entirely red or entirely blue uniform cubes.
When the two types of cubes are mixed together at room temperature (25 degrees Celsius, 77 degrees Fahrenheit), the red and blue building blocks automatically recombine into the most stable type of cubes, which are made of any combination of three red and three blue blocks. This mixture of red-blue cubes is analogous to well-mixed ink and water.
When researchers want to scramble the red-blue cubes to reform entirely red and entirely blue cubes, they do a simple two-step temperature change. This ability represents a chemical accomplishment not possible with a mixture of ink and water.
First, they heat the mixture up to boiling (100 degrees Celsius, 212 degrees Fahrenheit). The blue cubes become unstable and float off as individual molecules, while the red building blocks recombine into entirely red cubes.
Then, researchers rapidly cool the mixture (0 degrees Celsius, 32 degrees Fahrenheit) so that the red cubes stay together while the blue building blocks automatically assemble into entirely blue cubes.
Researchers can also prevent a mixture of entirely red and entirely blue cubes from scrambling into the more stable red-blue blended cubes by filling the cubes with something, for example other molecules like hydrocarbons. The guest molecules effectively lock the cubes closed from the inside so that the building blocks cannot scramble into other, more stable cube combinations.
"In the future, we plan to develop an even more complicated chemical system based on molecular cubes, using the unique self-assembly ability and a variety of energy sources beyond just heat," said Hiraoka.
Source: University of Tokyo
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