|May 30, 2022|
Multifunctional nanoplatform for efficient cancer photo-immunotherapy(Nanowerk News) Cancer immunotherapy is a treatment modality against tumor growth and metastasis by stimulating host immune responses. Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a less invasive treatment compared with chemotherapy. To be specific, PDT and PTT-induced immunogenic cell death can release tumor-associated antigens and damage-associated molecular patterns, stimulating an immune response.
|Photo-immunotherapy, the combination of phototherapy and immunotherapy, can effectively enhance treatment effectiveness compared with a single treatment modality. Up to now, the multifunctional photo-immune system is still in its infancy. Hence, the development of a multifunctional and safe photo-immunotherapy system for efficient tumor treatment is urgently needed.|
|DONG Wenfei's group from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences has recently developed a multifunctional nanoplatform based on mesoporous hexagonal core-shell zinc porphyrin-silica nanoparticles (MPSNs) loaded with R837 (a toll-like receptor-7 agonist), which can be used to integrate PDT, PTT, and tumor-specific immunotherapy for breast cancer (Journal of Nanobiotechnology, "Light-triggered multifunctional nanoplatform for efficient cancer photo-immunotherapy").|
|Schematic diagram of nanomaterials for photoimmunotherapy of breast cancer. (Image: SIBET)|
|According to the researchers, MPSNs with zinc phosphide (ZnP) as the core and a mesoporous silica framework as the shell could effectively generate singlet oxygen and convert photons to heat with a single light source.|
|Meanwhile, the excellent mesoporous structure of the silica shell can facilitate efficient R837 loading. Consequently, the therapeutic strategy based on [email protected] not only eradicated primary tumors via phototherapy modalities (PDT and PTT), but also effectively inhibited distant metastasis due to the strong immune response triggered by the two-way mechanistic interaction.|
|Source: Chinese Academy of Sciences|