| Nov 08, 2022 |
Magnetosome-inspired soft ferromagnetic nanoparticles with high magnetic targeting and tumor tissue penetration
(Nanowerk News) In a study published in PNAS ("Magnetosome-inspired synthesis of soft ferrimagnetic nanoparticles for magnetic tumor targeting"), a research team led by Prof. WANG Junfeng from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences biomimetically synthesized soft ferromagnetic nanoparticles with high magnetic targeting and tumor tissue penetration based on the biomineralization mechanism of natural "biocompass" - magnetotactic bacteria.
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| Magnetic navigation of magnetotactic bacterial and the magnetosome chains. (Image: MA Kun)
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Targeted delivery of anti-tumor drugs can effectively improve the efficacy and minimize the toxicity of drugs. Due to the limitations of the complexity of the tumor microenvironment, the average tumor targeting efficiency of nanodrugs is less than 1%, which constitutes one of the bottlenecks of tumor therapy.
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Animals like pigeons, turtles and lizards can use the geomagnetic field to navigate. The bacteria, after obtaining iron from the surrounding environment, can move directionally along the magnetic field in the geomagnetic or artificial magnetic field. The magnetosomes offer a wide range of application prospects thanks to their obvious advantages in magnetic properties, biocompatibility and stability.
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| A reverse micelle nanoreactor regulated by the Mms6 protein to simulate the biomineralization process in magnetotactic bacterial. (Image: MA Kun)
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However, natural magnetosome particles are easy to accumulate and precipitate in the external environment, which hinders their ability to penetrate the lesion area and the potential danger of deposition in blood vessels.
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In this work, the researchers proposed a new strategy for biomimetic synthesis of magnetosomes. They constructed a magnetosome-like nanoreactor, and reconstructed the microenvironment of magnetosomes biomineralization of magnetotactic bacteria in vitro.
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"The magnetosome-like nanoparticles synthesized with this method performed excellently," said MA Kun, first author of the study, "The DSPE-mPEG–coated magnetosome-like magnetic nanoparticles penetrated the lesion area of a tumor mouse model."
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| Magnetosomes have the same crystal morphology and magnetic properties as natural magnetosomes, can effectively respond to external magnetic field and achieve targeted enrichment and efficient penetration of tumor tissues. (Image: MA Kun)
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Experimental findings demonstrate the improvement by an order of magnitude in the targeting and penetrability of biomimetic magnetosomes in tumor tissues compared with other magnetic nanodrugs.
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This work not only provides an efficient carrier for magnetic targeting delivery of nanodrugs, and but also expands a new model system for studying the biomineralization mechanism of magnetotactic bacteria in vitro.
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