Posted: November 17, 2009 | |
IBM scientists reinvent medical diagnostic testing with new lab-on-chip |
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(Nanowerk News) IBM scientists have created a one-step point-of-care-diagnostic test, based on an innovative silicon chip that requires less sample volume, is significantly faster, portable, easy to use and can test for many diseases, including one of world's leading cause of death, cardiovascular disease. The results are so quick and accurate that a patient’s serum or blood sample, could be tested immediately following a myocardial infarction, commonly known as a heart attack, to enable the doctor to take a course of action and to predict the patients survival rate. | |
As reported in Lab on a Chip ("Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates ") IBM Research - Zurich scientists Luc Gervais and Emmanuel Delamarche in collaboration with the University Hospital of Basel in Switzerland have developed a new diagnostic test that uses capillary forces to analyze tiny samples of serum or blood for the presence of disease markers, which are typically proteins that can be detected in people’s blood for diagnostic purposes. Capillary action is the tendency of a liquid to rise in narrow tubes or to be drawn into small openings. An everyday example of a capillary action can be viewed by dipping a paper towel in a cup of water — the microstructures in the paper fiber enable the towel to absorb the water. | |
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In this photo we see the capillary pump, which has a depth of 180 micrometers and contains an intricate set of microstructures, the job of which is to pump the sample through the device for as long as needed and at a regular flow rate, just like the human heart. This pump makes the test accurate, portable and simple to use. IBM scientists have developed a library of capillary pumps so that tests needing a variety of sample volumes or test times can still be done without having to re-engineer the entire chip. (Image: Luc Gervais, IBM Research - Zurich) | |
All in the chip | |
IBM scientists have encoded the forces of capillary action on a microfluidic chip made of a silicon compound, similar to those used in computer chips, thus leveraging IBM's vast experience in developing and manufacturing silicon semiconductor wafers. The chip, which measures 1 × 5 centimeters, contains sets of micrometer wide channels where the test sample flows through in approximately 15 seconds, several times faster then traditional tests. Uniquely, the filling speed can be adjusted to several minutes when the chip requires additional time to read a more complex disease marker. | |
The microfludic chip, which is based on nearly three years of research and development, consists of a microscopic path for liquids with five innovative stages: | |
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"This point of care test has achieved the trifecta for medical staff in that it is portable, fast and requires a very small volume of sample," comments Emmanuel Delamarche, scientist, IBM Research - Zurich. "We are giving back precious minutes to doctors so they can make informed and accurate decisions right at the time they need them most to save lives". | |
Going to market | |
Proof positive of IBM's strategy of open collaboration, scientists in Zurich followed a “bench to bedside” strategy where ideas from their lab were tested with academic and healthcare partners. This research also would not have been possible without the generous support of KTI/CTI, an organization which fosters innovation in Switzerland. | |
"This microfluidic chip is the next step in the evolution of point of care devices. We look forward to working with the scientists at IBM Research - Zurich to develop this innovation even further," said Thierry Leclipteux, Chief Executive Officer and Chief Science Officer, Coris BioConcept. | |
IBM scientists designed the chip with flexibility in mind in both its form and uses. Due to its small size the chip can be embedded in several types of form factors, depending on the application, including a credit card, a pen or something similar to a pregnancy test. Besides diagnosing diseases, the test is also flexible enough to test for chemical and bio hazards. |
Source: IBM |
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