Researchers report a step toward development of a new type of antibiotic using proteins from marine diatoms. The above diatoms were living between crystals of sea ice in McMurdo Sound, Antarctica. (Image: NOAA)
In the new study, D. Matthew Eby, Glenn Johnson, and Karen Farrington point out that scientists have long eyed the germ-fighting potential of antimicrobial peptides (AMPs). These small proteins fight a wide range of bacteria and fungi in the body and have the potential to be developed into powerful drugs to overcome infections that are resistant to conventional drugs. But scientists report difficulty producing effective AMPs because the antibiotics are fragile and easily destroyed in the body. An effective way to stabilize them is needed, they say.
In laboratory studies, the researchers showed that the coating protected the antibiotics from destruction by other chemicals while allowing the release of a controlled antibiotic dose for an extended period of time. These features are key to the effective use of AMPs as antibiotics, they say.