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Posted: April 23, 2010

UV imaging - a new approach for in vitro dissolution and release testing

(Nanowerk News) The Drug Research Academy at the Faculty of Pharmaceutical Sciences, University of Copenhagen and Paraytec (York, UK) announce the first mini-symposium on surface dissolution imaging, which will be held in the University of Copenhagen on 19th May 2010.
Presentations will be given by leading academic and industrial researchers. The meeting will discuss fundamental principles behind the technique, examples of analysis and interpretation of a range of sparingly soluble species and how this technique can assist pre-formulation labs develop better active pharmaceutical ingredients via a quality by design approach.
Jesper Ostergaard, Associate Professor at the Department of Pharmaceutics and Analytical Chemistry at the University of Copenhagen and symposium chair commented “UV imaging facilitates quantification of the drug substance immediately adjacent to the solid material (or drug formulation) and the recording of concentration gradients. In principle, this will allow for faster and more detailed studies of drug dissolution as compared to the traditional methods. We are looking forward to the symposium which will highlight recent applications and discuss the potential of this novel, interesting dissolution technology”.
Symposium details
Time of symposium: Wednesday, May 19, 2010 at 13:30 – 17:00 hrs
Location: Benzon Auditorium, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen
The symposium program is available to view on: http://www.farma.ku.dk/index.php/UV-imaging-a-new-approach-fo/7783/0/
The event is free to attend. To register, please email info@paraytec.com
Dissolution is frequently the rate-controlling step in drug absorption of poorly soluble drugs. In the commonly used dissolution methods the concentration of dissolved substance is measured in the bulk release media. In principle faster and more detailed studies of drug dissolution may be achieved if the dissolution can be measured at the solid-liquid interface. With UV imaging it is possible to measure the intensity of light passing through an area of a quartz tube as a function of position and time. Thus, UV imaging facilitates quantification of drug substances in solution immediately adjacent to the solid material and recording of concentration gradients (7 ?m × 7 ?m pixel size). This symposium will highlight applications and discuss the potential of the novel, interesting dissolution imaging technology.
The ActiPix SDI300 instrument is a unique UV area imaging detector which enables quantitative imaging of surface phenomena of a diverse range of substances including APIs, formulations, gels, liquids, stents and patches.
Compact in design, the SDI300 system includes patented ActiPix™ UV area imaging detection, dissolution imaging sample holder, integrated syringe pump, and software which enables real time quantitative recording and review of data. The SDI300 uses a highly sensitive UV area imaging sensor to record, interrogate and analyse a variety of complex processes. Operating wavelength (190-1100 nm) can be selected to allow sensitive and selective monitoring of the substance of interest. It is the first tool of its kind to offer accurate, quantitative and mechanistic information for a variety of applications. Used as a tool for accelerated pre-formulation development the SDI300 is proven to enable intrinsic dissolution rates to be obtained in less than 20 minutes, a fraction of the time compared to conventional dissolution systems. The ActiPix™ SDI300 provides unique insights into processes taking place from microns to millimetres from the surface, the key distance range for understanding dissolution, and enables both erosion and dissolution to be vizualised simultaneously.
Source: Paraytec
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