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Building heart tissue that beat

When a heart gets damaged, such as during a major heart attack, there's no easy fix. But scientists working on a way to repair the vital organ have now engineered tissue that closely mimics natural heart muscle that beats, not only in a lab dish but also when implanted into animals.

Mar 18th, 2014

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New DNA-editing technology spawns bold university initiative

The University of California, Berkeley, and UC San Francisco are launching the Innovative Genomics Initiative (to lead a revolution in genetic engineering based on a new technology already generating novel strategies for gene therapy and the genetic study of disease.

Mar 18th, 2014

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In the lab, scientists coax E. coli to resist radiation damage

Capitalizing on the ability of an organism to evolve in response to punishment from a hostile environment, scientists have coaxed the model bacterium Escherichia coli to dramatically resist ionizing radiation and, in the process, reveal the genetic mechanisms that make the feat possible.

Mar 14th, 2014

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'Velcro protein' found to play surprising role in cell migration

Studying epithelial cells, the cell type that most commonly turns cancerous, Johns Hopkins researchers have identified a protein that causes cells to release from their neighbors and migrate away from healthy mammary, or breast, tissue in mice. They also found that deletion of a cellular 'Velcro protein' does not cause the single-celled migration expected. Their results, they say, help clarify the molecular changes required for cancer cells to metastasize.

Mar 13th, 2014

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Stirring the simmering 'designer baby' pot

From genetic and genomic testing to new techniques in human assisted reproduction, various technologies are providing parents with more of a say about the children they have and 'stirring the pot of designer baby concerns', writes Thomas H. Murray, President Emeritus of The Hastings Center, in a commentary in Science.

Mar 13th, 2014

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A new bioinformatics tool to visualize transcriptomes

ZENBU, a new, freely available bioinformatics tool developed at the RIKEN Center for Life Science Technology in Japan, enables researchers to quickly and easily integrate, visualize and compare large amounts of genomic information resulting from large-scale, next-generation sequencing experiments.

Mar 11th, 2014

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Computational tool offers new insight into key biological processes

Researchers have developed a computational tool designed to guide future research on biochemical pathways by identifying which components in a biological system are related to specific biochemical processes, including those processes responsible for gene expression, cell signaling, stress response, and metabolism.

Mar 6th, 2014

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Enzyme controls transport of genomic building blocks

Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain gene regulatory information. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent diseases as cancer.

Mar 6th, 2014

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New molecules doom proteins with kiss of death

Like mobsters following strict orders, newly engineered molecules called 'ubiquibodies' can mark specific proteins inside a cell for destruction. It's a molecular kiss of death developed at Cornell University that is paving the way for new drug therapies and powerful research tools.

Mar 5th, 2014

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