|Posted: December 24, 2008|
Preparing an anticancer drug carrier via crystallization of nanoparticles
|(Nanowerk News) A research team led by Prof. MA Guanghui with the Chinese Academy of Sciences (CAS) Institute of Processing Engineering has developed a one-pot approach to couple the crystallization of CaCO3 nanoparticles and the in-situ symmetry-breaking assembly of these crystallites into hollow spherical shells under the templating effect of a soluble starch. Their work was published in a recent issue of Journal of American Chemical Society.|
|Their further functional studies using HP-a as an anticancer drug carrier demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.|
|The work was supported by the National Natural Science Foundation of China, CAS, and Ministry of Science and Technology, respectively.|
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