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Posted: Feb 06, 2013
Nanoscale capsule effectively kills cancer cells
(Nanowerk News) A tiny capsule invented at a UCLA lab could go a long way toward improving cancer treatment.
Devising a method for more precise and less invasive treatment of cancer tumors, a team led by researchers from the UCLA Henry Samueli School of Engineering and Applied Science has developed a degradable nanoscale shell to carry proteins to cancer cells and stunt the growth of tumors without damaging healthy cells.
A diagram of the synthesis of degradable nanocapsules into cell nuclei to induce apoptosis, or programmed cell death, in cancer cells. The nanocapsules degrade harmlessly in normal cells.
The process does not present the risk of genetic mutation posed by gene therapies for cancer, or the risk to healthy cells caused by chemotherapy, which does not effectively discriminate between healthy and cancerous cells, Tang said.
"This approach is potentially a new way to treat cancer," said Tang. "It is a difficult problem to deliver the protein if we don't use this vehicle. This is a unique way to treat cancer cells and leave healthy cells untouched."
The cell-destroying material, apoptin, is a protein complex derived from an anemia virus in birds. This protein cargo accumulates in the nucleus of cancer cells and signals to the cell to undergo programmed self-destruction.
The polymer shells are developed under mild physiological conditions so as not to alter the chemical structure of the proteins or cause them to clump, preserving their effectiveness on the cancer cells.
Tests done on human breast cancer cell lines in laboratory mice showed significant reduction in tumor growth.
"Delivering a large protein complex such as apoptin to the innermost compartment of tumor cells was a challenge, but the reversible polymer encapsulation strategy was very effective in protecting and escorting the cargo in its functional form," said Muxun Zhao, lead author of the research and a graduate student in chemical and biomolecular engineering at UCLA.
Tang's group continues to research ways of more precisely targeting tumors, prolonging the circulation time of the capsules and delivering other highly sought-after proteins to cancer cells.
The research team also included former UCLA Engineering student Zhen Gu, now an assistant professor in the joint biomedical engineering department at the University of North Carolina at Chapel Hill and North Carolina State University, and University of Southern California researchers including graduate student Biliang Hu, postdoctoral scholar Kye-Il Joo and associate professor Pin Wang.
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