In new research from Brigham and Women's Hospital (BWH), researchers describe the design and effectiveness of a first-of-its-kind, self assembled, multi-functional, NIR responsive gold nanorods that can deliver a chemotherapy drug specifically targeted to cancer cells and selectively release the drug in response to an external beam of light while creating heat for synergistic thermo-chemo mediated anti-tumor efficacy.
Researchers have long sought to use magnetic fields to increase the concentration of drug-loaded iron oxide nanoparticles that reach a tumor. However, magnetic fields drop off quickly with distance, making it almost impossible to consider such an approach for tumors located more than a few centimeters from the skin. To solve what appears to be a fundamentally unsolvable problem, researchers have now taken a two-pronged approach, one that uses an external magnetic field and an implantable magnetizable mesh to create local magnetic fields strong enough to trap nanoparticles at a specific location.
One of the hallmarks of cancer is that tumors alter the tissues that surround malignant cells. A team of investigators from Johns Hopkins has taken advantage of this hallmark to develop a new approach to identifying cancer that hones in on collagen that gets degraded as a tumor grows.
A new study by researchers at the University of Kentucky Cancer Nanotechnology Platform Partnership (Kentucky CNPP) shows promise for developing ultrastable RNA nanoparticles that may help treat cancer by regulating cell function and binding to tumors without harming surrounding tissue.
Researchers from the Johns Hopkins Center of Cancer Nanotechnology Excellence (Hopkins CCNE) report they are one step closer to a drug-delivery system flexible enough to overcome some key challenges posed by brain cancer and other maladies affecting the brain.
An international research group led by scientists from the University of Bristol and the Universities of Glasgow (UK) and Sun Yat-sen and Fudan in China, have demonstrated integrated arrays of emitters of so call 'optical vortex beams' onto a silicon chip.
Chemists at the California Institute of Technology (Caltech) have managed, for the first time, to simulate the biological function of a channel called the Sec translocon, which allows specific proteins to pass through membranes.
A thread of research pursued in a pan-European collaboration lead by Aalto University Department of Applied Physics scientists has yielded prominent results for the electron microscopy of nitrogen-doped graphene and carbon nanotubes.