A clearer understanding of the origin recognition complex (ORC) - a protein complex that directs DNA replication - through its crystal structure offers new insight into fundamental mechanisms of DNA replication initiation. This will also provide insight into how ORC may be compromised in a subset of patients with Meier-Gorlin syndrome, a form of dwarfism in humans.
Scientists develop world's first continuous purification method for valuable drugs. This will lead to significantly reduced production costs and to cheaper pharmaceuticals that are affordable for non-privileged health care systems.
One of life's strongest bonds has been discovered by a science team researching biofuels with the help of supercomputers. Their find could boost efforts to develop catalysts for biofuel production from non-food waste plants.
Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, researchers have established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.
A research collaboration develops a new open access tool called PolyMaker that will support the selection of beneficial traits for future crop breeding programmes. The new software enables automated primer design for multiple genome species, significantly reducing the time of multiple genome analysis.
Researchers have managed to bond positively charged phosphorus atoms with positively charged hydrogen ones. Their insight may prove pivotal to understanding how biologically important molecules such as DNA and proteins form properly.
Scientists have created a 3-D model of a complex protein machine, ORC, which helps prepare DNA to be duplicated. But the new information has uncovered another mystery: ORC's structure reveals that it is not always ?on? as was previously thought, and no one knows how it turns on and off.
Researchers have developed a new injectable polymer that strengthens blood clots, called PolySTAT. Administered in a simple shot, the polymer finds any unseen or internal injuries and starts working immediately.
The new system - called BASIC - is a major advance for the field of synthetic biology, which designs and builds organisms able to make useful products such as medicines, energy, food, materials and chemicals.