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'Programmable' antibiotic harnesses an enzyme to attack drug-resistant microbes

Conventional antibiotics are indiscriminate about what they kill, a trait that can lead to complications for patients and can contribute to the growing problems of antibiotic resistance. But a a 'programmable' antibiotic being developed at Rockefeller would selectively target only the bad bugs, particularly those harboring antibiotic resistance genes, and leave beneficial microbes alone.

Posted: Oct 5th, 2014

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RCas9: A programmable RNA editing tool

A powerful scientific tool for editing the DNA instructions in a genome can now also be applied to RNA as researchers have demonstrated a means by which the CRISPR/Cas9 protein complex can be programmed to recognize and cleave RNA at sequence-specific target sites.

Posted: Oct 3rd, 2014

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High-throughput cell-sorting method can separate 10 billion bacterial cells in 30 minutes

A mechanical engineer has developed a new, high-throughput method for sorting cells capable of separating 10 billion bacterial cells in 30 minutes. The finding has already proven useful for studying bacterial cells and microalgae, and could one day have direct applications for biomedical research and environmental science - basically any field in which a large quantity of microbial samples need to be processed.

Posted: Sep 26th, 2014

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Unlocking long-hidden mechanisms of plant cell division

Scientists present a detailed new model that for the first time proposes how plant cells precisely position a 'dynamic and complex' structure called a phragmoplast at the cell center during every division and how it directs cytokinesis.

Posted: Sep 25th, 2014

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DARPA awards $7.9M to build an artificial immune system

Scientists from both campuses of The Scripps Research Institute (TSRI) have been awarded a total of $7.9 million from the Defense Advanced Research Projects Agency (DARPA). The two teams will build what is, in essence, an artificial immune system, comprising vast 'libraries' of different types of molecules from which will emerge individual compounds to detect or neutralize an array of biological and chemical threats.

Posted: Sep 24th, 2014

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Battling superbugs with new biotechnologies

Using a gene-editing system that can disable any target gene, researchers have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease.

Posted: Sep 23rd, 2014

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The accelerator of molecular motors

Researchers have successfully identified the 'molecular accelerator' that activates the peroxisomal processes. To their surprise, it turned out to be an old acquaintance: a certain module of the familiar protein Pex22p, which has hitherto always been considered an anchor protein.

Posted: Sep 22nd, 2014

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