By combining microbiology with engineering technologies, researchers are developing a first-of-its-kind 3D model that uses a single microfluidic sensing chip to study the complicated processes that take place in malaria-infected placenta as well as other placenta-related diseases and pathologies.
New research on a crucial protein in fruit flies provides a clear model for a fundamental question in biology that's significant for drug development in particular: What influences the exact same protein to coordinate a vital molecular process on one chromosome but an entirely different one on another chromosome?
The development of DNA sensor systems is of great importance for advances in medical science. Now another piece of the puzzle for the development of personalized medicine has been found with the results of a highly sensitive monitoring of cancer-related topoisomerase II enzymes.
When chemically modified, this 'alginate' reduces oxidative stress, has an anti-inflammatory effect in cell culture tests and suppresses the immune reaction against cartilage cells, thereby combating the causes of arthritis.
A new data analysis technique, moving subtrajectory analysis, defines the dynamics and kinetics of key molecules in the immune response to an infection. These biophysical descriptions are expected to clarify the TCR microcluster, an essential assembly for a T cell to initiate its attack on a pathogen.