Biochemists have made a discovery that sheds light on the molecular machinery that allows some cells, such as immune cells or even malignant cancer cells in humans, to wiggle their way through tissues like organs, skin or bones.
Researchers have demonstrated a motion capture-like technology that tracks how proteins fold and change shape using fluorescent probes. The research could lead to improvements in drugs used to treat neurodegenerative diseases, as well as new methods of imaging that may also allow for earlier detection.
The burst of cells forming cartilage is associated with mineralization during the early stages of bone formation, and nanofragments of the cell membranes can act as nucleation sites for amorphous calcium phosphate.
Chemical engineers have developed a new, cost-effective method for synthetically producing a biorenewable platform chemical called triacetic acid lactone (TAL) that can be used to produce innovative new drugs and sustainable plastics at an industrial scale.
Researchers have grown organoids from liver tumors on specially engineered 3-D scaffolds. These organoids replicate important features of the original tumor, including genetic changes and intra-tumor heterogeneity, and could serve as tumor avatars for high-throughput drug screening.
Despite subzero temperatures, increased UV radiation, little liquid water, and few available nutrients, bacteria living at Earth's poles thrive. They manage it thanks in part to molecules called biosurfactants, which help them separate the complex substrates they feed on into easy-to-metabolize droplets.