Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process. Researchers now have been able to resolve this issue by tracking the effects in a new, natural model.
Researchers have produced the first three-dimensional (3D) map of a molecular 'scaffold' called SgK223, known to play a critical role in the development and spread of aggressive breast, colon and pancreatic cancers.
By combining engineered hydrogels with complex intestinal tissue known as organoids - made from human pluripotent stem cells - researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut.