Scientists from both campuses of The Scripps Research Institute (TSRI) have been awarded a total of $7.9 million from the Defense Advanced Research Projects Agency (DARPA). The two teams will build what is, in essence, an artificial immune system, comprising vast 'libraries' of different types of molecules from which will emerge individual compounds to detect or neutralize an array of biological and chemical threats.
When the body forms new tissues during the healing process, cells must be able to communicate with each other. For years, scientists believed this communication happened primarily through chemical signaling. Now researchers have found that another dimension - mechanical communication - is equally if not more crucial.
Scientists try to understand how networks of genes work together to create specific patterns like stripes. They have gone beyond studying individual networks and have created computational and synthetic mechanisms for a whole 'design space' of networks in the bacteria Escherichia coli.
Scientists have established an easy to use, low-cost, rapid, and high sensitivity semiconductor-imaging based medical diagnostic biosensing system for analyzing blood and urine for early diagnosis of ailments including diabetes and Alzheimer's disease.
Researchers have successfully identified the 'molecular accelerator' that activates the peroxisomal processes. To their surprise, it turned out to be an old acquaintance: a certain module of the familiar protein Pex22p, which has hitherto always been considered an anchor protein.
Crystals of membrane proteins and protein complexes often diffract to low resolution owing to their intrinsic molecular flexibility, heterogeneity or the mosaic spread of micro-domains. At low resolution, the building and refinement of atomic models is a more challenging task. The deformable elastic network refinement method developed previously has been instrumental in the determination of several structures at low resolution. Here, DEN refinement is reviewed.
Researchers have developed a new cocktail that coaxes adult cells to become pluripotent stem cells of a high enough quality to be used in therapeutic applications. Their research showed that using a different combination of reprogramming factors can produce a much higher quality result, delivering fewer colonies of iPSCs of which 80 percent passed the toughest pluripotency test.
Scientists have identified a highly sensitive means of analyzing very tiny amounts of DNA. The discovery, they say, could increase the ability of forensic scientists to match genetic material in some criminal investigations. It could also prevent the need for a painful, invasive test given to transplant patients at risk of rejecting their donor organs and replace it with a blood test that reveals traces of donor DNA.
Researchers have developed a new approach to measure proteins with structures that change. This could enable new diagnostic tools for the early recognition of neurodegenerative diseases to be developed.