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Lab-grown, virus-free stem cells repair retinal tissue in mice

Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice. The stem cells, derived from human umbilical cord-blood and coaxed into an embryonic-like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

Posted: Jan 24th, 2014

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Tracing unique cells with mathematics

Stem cells can turn into heart cells, skin cells can mutate to cancer cells; even cells of the same tissue type exhibit small heterogeneities. Scientists use single-cell analyses to investigate these heterogeneities. But the method is still laborious and considerable inaccuracies conceal smaller effects. Scientists have now found a way to simplify and improve the analysis by mathematical methods.

Posted: Jan 23rd, 2014

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Live feed into our bodies

A palm-top device developed by UCSB researchers provides real-time insight into how fast a living body metabolizes drugs, opening the door to highly personalized medicine.

Posted: Jan 22nd, 2014

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Insights into the structure of a protein transport assistant

Proteins are the molecular building blocks and machines of the cell and are involved in virtually every process of life. After protein production, many proteins are equipped with attachments such as sugar residues in order to perform their tasks properly. This process is directly coupled to the transport across a membrane. Employing various methods of structural biology, scientists have now gained insights into the architecture of the protein complex responsible for this process.

Posted: Jan 15th, 2014

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European network to carry out research on protein life cycle

The Proteostasis initiative, supported by the European Union (EU), is led by the Basque centre for research in biosciences, CIC bioGUNE, in collaboration with the Inbiomed foundation, and includes groups that carry out research on the degradation and modification of cellular proteins.

Posted: Jan 13th, 2014

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Scientists control cells following transplantation, from the inside out

Harvard stem cells scientists at Brigham and Women's Hospital and MIT can now engineer cells that are more easily controlled following transplantation, potentially making cell therapies, hundreds of which are currently in clinical trials across the United States, more functional and efficient.

Posted: Jan 10th, 2014

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Stem cells injected into nerve guide tubes repair injured peripheral nerve

When autologous, skin-derived stem cells were transplanted within collagen nerve guide tubes aimed at bridging gaps in damaged nerves, into the upper arms of a patient who was suffering peripheral nerve damage, the procedure successfully led to the rescue of peripheral nerves. The procedure spared the patient with poly-injury to motor and sensory nerve damage from amputation of the upper arms and resulted in 'suitable functional recovery'. Three year follow up revealed nerve regeneration.

Posted: Jan 10th, 2014

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Researchers develop artificial bone marrow

Artificial bone marrow may be used to reproduce hematopoietic stem cells. A prototype has now been developed. The porous structure possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory.

Posted: Jan 10th, 2014

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