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3-D maps reveal the genome's origami code (w/video)

In a triumph for cell biology, researchers have assembled the first high-resolution, 3-D maps of entire folded genomes and found a structural basis for gene regulation - a kind of 'genomic origami' that allows the same genome to produce different types of cells.

Posted: Dec 11th, 2014

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Now researchers can see how unfolded proteins move in the cell

When a large protein unfolds in transit through a cell, it slows down and can get stuck in traffic. Using a specialized microscope , researchers now can watch the way the unfolded protein diffuses. Studying the relationship between protein folding and transport could provide great insight into protein-misfolding diseases such as Alzheimer's and Huntington's.

Posted: Dec 10th, 2014

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Molecular decoys help overcome drug resistance

Efflux pumps are surface proteins that prevent antimicrobial drugs from getting a foothold in a bacterial cell by identifying and pumping them out of the cell. New research suggests that small pieces of those drugs could keep the efflux pumps busy and allow the antimicrobial drugs to reach a critical mass inside the cell.

Posted: Dec 9th, 2014

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Stain every nerve

Scientists can now explore nerves in mice in much greater detail than ever before, thanks to an approach developed by scientists at the European Molecular Biology Laboratory (EMBL). The work enables researchers to easily use artificial tags, broadening the range of what they can study and vastly increasing image resolution.

Posted: Dec 9th, 2014

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Technology breakthrough reveals cellular transcription process

This new research tool offers a more profound view of the immune responses that are involved in a range of diseases, such as HIV infection. At the level of gene transcription, this had been difficult, complex and costly to do with current technologies, such as microscopy.

Posted: Dec 4th, 2014

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Researchers control adhesion of E. coli bacteria

Researchers created a synthetic surface on which the adhesion of E. coli bacteria can be controlled. The layer, which is only approximately four nanometres thick, imitates the saccharide coating (glycocalyx) of cells onto which the bacteria adhere such as during an infection.

Posted: Dec 2nd, 2014

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A new tool for exploring cells in 3D

Researchers can now explore viruses, bacteria and components of the human body in more detail than ever before with software developed at The Scripps Research Institute (TSRI).

Posted: Dec 2nd, 2014

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Proteins off the roll

Protein-coated Petri dishes are increasingly being used to support cell growth during cell cultivation. Scientists have developed a system for printing protein patterns onto film using a roll-to-roll process, which allows high volumes to be manufactured efficiently and cost-effectively.

Posted: Dec 1st, 2014

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Classical enzymatic theory revised by including water motions

The main focus of enzymology lies on enzymes themselves, whereas the role of water motions in mediating the biological reaction is often left aside owing to the complex molecular behavior. Researchers have revised the classical enzymatic steady state theory by including long-lasting protein-water coupled motions into models of functional catalysis.

Posted: Nov 26th, 2014

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