Cedars-Sinai Heart Institute researchers have reprogrammed ordinary heart cells to become exact replicas of highly specialized pacemaker cells by injecting a single gene (Tbx18) - a major step forward in the decade-long search for a biological therapy to correct erratic and failing heartbeats.
The software, which will be used to control Organovo's NovoGen MMX bioprinter, will represent a major step forward in usability and functionality for designing three-dimensional human tissues, and has the potential to open up bioprinting to a broader group of users.
Scientists at The University of Manchester have identified a biocatalyst which could produce chemicals found in ice-cream and household items such as soap and shampoo - possibly leading to the long-term replacement of chemicals derived from fossil fuels.
Building a tunnel made up of both hard and soft materials to guide the reconnection of severed nerve endings may be the first step toward helping patients who have suffered extensive nerve trauma regain feeling and movement, according to a team of biomedical engineers.
A new model of the how the protein coat of viruses assembles shows that the construction of intermediate structures prior to final capsid production (hierarchical assembly) can be more efficient than constructing the capsid protein by protein (direct assembly).
Researchers have developed a platform that compiles all the atomic data, previously stored in diverse databases, on protein structures and protein interactions for eight organisms of relevance. They apply a singular homology-based modelling procedure.
Researchers at the University of Virginia School of Medicine have deciphered the secrets of the production of cellulose, the most common natural polymer on Earth, in a discovery that could have major ramifications for both biofuel production and the battle against bacterial infections.
Scientists have long sought to understand how a DNA repair protein, known as RecA in bacterial cells, helps broken DNA find a way to bridge the gap. In a new study, researchers report they have identified how the RecA protein does its job.
This study sheds new light on how cells manage to keep traffic flowing smoothly along this busy transportation network that is vital to the survival of cells and whose failure can lead to a variety of diseases, including Alzheimer's and cancer.
An international collaboration between researchers at the Babraham Institute, Cancer Research UK's London Research Institute, Imperial College London and Amherst College in the US, has revealed an instrumental molecule in ensuring that the nuclear membrane reforms correctly after cell division, and therefore plays a key role maintaining the delicate balance between cell growth and cell death.
Scientists at the Max Planck Institute for Chemical Energy Conversion have solved a long-standing puzzle in photosynthesis research. With the aid of quantum chemistry they were able to provide unexpected insight into the properties of the oxygen evolving complex (OEC).