Certain genetic diseases arise from a deficit of specific genes. An enzyme that amplifies gene transcription could be a viable therapy in these cases, as long as genes are not stimulated to work on the wrong part of the body. SISSA scientists have created synthetic 'intelligent' enzymes which are able to differentiate between active and inactive genes and selectively stimulate the former ones.
Surveying everything from sea cucumbers and Venus flytraps to human muscles and trees, a new review paper broadly explores the strategies that biology employs to create different functions and the mechanics at play within those functions. Discovering how and why biological systems attain desirable static and dynamic mechanical functionalities often reveals principles that inform new synthetic designs based on biological systems.
Scientists have managed to capture and describe a protein structure that, until now, has been impossible to study. The discovery lays the base for developing designed enzymes as catalysts to new chemical reactions for instance in biotechnological applications.
Scientists have demonstrated that the Earth's daily rotation period (24 hours) is encoded in the KaiC protein at the atomic level, a small, 10 nm-diameter biomolecule expressed in cyanobacterial cells.
Researchers describe building a new pathway that lets the bacterium, E. coli, feed on both sugar (glucose) and acetate, a common waste material from biomass, to make isobutyl acetate. This product can be used as the basis for flavoring agents, solvents and fuels.
Researchers have, for the first time, uncovered the complex interdependence and orchestration of metabolic reactions, gene regulation, and environmental cues of clostridial metabolism, providing new insights for advanced biofuel development.
The three-year clinical trial results of the retinal implant popularly known as the 'bionic eye', have proven the long-term efficacy, safety and reliability of the device that restores vision in those blinded by a rare, degenerative eye disease. The findings show that the Argus II significantly improves visual function and quality of life for people blinded by retinitis pigmentosa.
X-rays were used to measure the ultrafast response of DNA nucleobases to ultraviolet light. Researchers found that the UV excited state in the nucleobase thymine decays rapidly, harmlessly dissipating the potentially destructive UV energy.