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Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics

A clearer understanding of the origin recognition complex (ORC) - a protein complex that directs DNA replication - through its crystal structure offers new insight into fundamental mechanisms of DNA replication initiation. This will also provide insight into how ORC may be compromised in a subset of patients with Meier-Gorlin syndrome, a form of dwarfism in humans.

Posted: Mar 18th, 2015

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Researchers establish proof of concept for an entirely new approach to drug design

Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, researchers have established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.

Posted: Mar 16th, 2015

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Chemists discover an unlikely connection

Researchers have managed to bond positively charged phosphorus atoms with positively charged hydrogen ones. Their insight may prove pivotal to understanding how biologically important molecules such as DNA and proteins form properly.

Posted: Mar 13th, 2015

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