Researchers have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.
Researchers have created a 'heart-on-a-chip' that effectively uses human cardiac muscle cells derived from adult stem cells to model how a human heart reacts to cardiovascular medications. The system could one day replace animal models to screen for the safety and efficacy of new drugs.
After its success in the first joint call by ERASynBio, the collaborative project Synthetic Glycobiology - new strategies to build and functionalise proto-cells and proto-tissues is now set to receive roughly 1.9 million euros in total funding.
Modern biology has attained deep knowledge of how cells work, but the mechanisms by which cellular structures assemble and grow to the right size largely remain a mystery. Now, Princeton University researchers may have found the key in a dynamic agglomeration of molecules inside cells.
With the aid of X-ray crystallography, researchers have revealed the structures of two closely related enzymes that play essential roles in the body's ability to metabolize excess lipids, including cholesterol.
Bacteria that talk to one another and organize themselves into biofilms are more resistant to antibiotics. Researchers are now working to develop drugs that prevent bacteria from communicating. The aim is to find alternatives to antibiotics and reduce the number of antibiotic-resistant bacteria.
How can a humpback whale and a device that works on the same principle as the clicker that starts your gas grill help an unmanned aerial vehicle (UAV) fly longer and with more stability? Well, it all starts with biological structures called tubercles that the whale uses for its unique maneuvers in the ocean.
Unable to move and facing starvation, bacteria evolved a new way to activate their flagellum - a rotating tail-like structure which acts like an outboard motor - by patching together a new genetic switch with borrowed parts.