ZENBU, a new, freely available bioinformatics tool developed at the RIKEN Center for Life Science Technology in Japan, enables researchers to quickly and easily integrate, visualize and compare large amounts of genomic information resulting from large-scale, next-generation sequencing experiments.
In a significant advance for the growing field of synthetic biology, bioengineers have created a toolkit of genes and hardware that uses colored lights and engineered bacteria to bring both mathematical predictability and cut-and-paste simplicity to the world of genetic circuit design.
Researchers have developed a computational tool designed to guide future research on biochemical pathways by identifying which components in a biological system are related to specific biochemical processes, including those processes responsible for gene expression, cell signaling, stress response, and metabolism.
Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain gene regulatory information. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent diseases as cancer.
Like mobsters following strict orders, newly engineered molecules called 'ubiquibodies' can mark specific proteins inside a cell for destruction. It's a molecular kiss of death developed at Cornell University that is paving the way for new drug therapies and powerful research tools.
Scientists at The Scripps Research Institute have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.
Researchers have developed a new method that allows scientists to pinpoint thousands of mRNAs and other types of RNAs at once in intact cells - all while determining the sequence of letters, or bases, that identify them and reveal what they do.
At Deutsches Elektronen-Synchrotron's PETRA III research light source, scientists have carried out the first studies of living biological cells using high-energy X-rays. The new method for the first time enables us to investigate the internal structures of living cells in their natural environment using hard X-rays.
Chemists from Radboud University Nijmegen and the Foundation for Fundamental Research on Matter (FOM) have succeeded in producing detailed 3D structures of selected peptides - the building blocks of proteins.