A new breakthrough technology facilitates DNA delivery into drug-resistant bacterial pathogens, enabling their manipulation. The research expands the range of bacteriophages, which are the primary tool for introducing DNA into pathogenic bacteria to neutralize their lethal activity.
Every human being has a unique DNA 'fingerprint'. In other words, the genetic material of any two individuals can be clearly distinguished. Computational biologists have now determined that the impact of these variations has been greatly underestimated. The new insights could importantly impact advances in personalized medicine.
Scientists have developed a method to visualize defined genomic sequences in living plant cells and demonstrated its ability to reveal dynamic movements of chromosome ends. This method allows the analysis of the spatio-temporal organization of the genome.
An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes - greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.
Biomedical engineers have created a lab-grown tissue similar to natural cartilage by giving it a bit of a stretch. The tissue, grown under tension but without a supporting scaffold, shows similar mechanical and biochemical properties to natural cartilage.
The novel method keeps cells alive for multiple weeks, which makes it easier to study them. This makes it possible to, for example, test the action of new drugs and improve stem cell therapies with unparalleled control.