Researchers used machine learning on a supercomputer to model the cellular control network that determines how tadpoles develop. Using that model, they reverse-engineered a drug intervention that created tadpoles with a form of mixed pigmentation never before seen in nature. They plan to use the method for cancer therapies and regenerative medicine.
For the first time, researchers have applied single-cell transcriptomics to colorectal cancer (CRC) and discovered that this method could lead to improved patient stratification and eventually, a more accurate prognosis of CRC patients.
A newly developed elastic gel administered in liquid form and shown to turn jellylike within minutes after injection into rabbits' eyes to replace the clear gelatinous fluid inside their eyeballs, may help pave the way for new eye surgery techniques.
The approach used involves the autologous transplantation of bioengineered tooth germ into a canine jawbone; the in vivo artificially created tooth has the structure, composition and physiological characteristics of a natural tooth.
The model system, based on E. coli, contained the bare minimum for assembling proteins: 241 chemicals undergoing 968 reactions for 1,000 seconds. Many of these chemicals twice reached steady concentrations, only to be suddenly depleted at a later stage.
Scientists have discovered which genes from the yeast genome exhibit dosage compensation - the ability to temper protein production when the corresponding encoding gene?s copy number increases. In addition, they identify the underlying process to be protein degradation, and link the mechanism to stoichiometric buffering of protein complex subunits.