A microreactor developed as part of a collaborative research project enables cultured liver cells to be used as test samples. Unlike animal testing, this novel method enables the assessment of potentially toxic substances on tissue in real time.
Researchers have developed a range of synthetic biomimetic compounds to replace the relatively expensive natural NADH and NADPH coenzymes in enzymatic conversions of industrial relevance. They show that some of the compounds even outperform their natural counterparts.
Researchers improved on existing technologies to create a modified single-stranded DNA molecule called aptamer. DNA aptamers are ideal for pharmaceutical applications because they can specifically bind to any molecular target in the body such as proteins, viruses, bacteria and cells.
Researchers have developed a new biodegradable material with built-in vitamin A, which has been shown to reduce scarring in blood vessels. This soft elastic material can be used to treat injured vessels or be used to make medical devices, such as stents and prosthetic vascular grafts, to give them intrinsic healing properties.
Engineered liver tissue could have a range of important uses, from transplants in patients suffering from the organ?s failure to pharmaceutical testing. Now scientists report the development of such a tissue, which closely mimics the liver?s complicated microstructure and function more effectively than existing models.
Scientists have discovered a molecule that interrupts biochemical signals essential for the survival of tumor cells called Wnt-addicted cancer stem cells. The discovery is the product of an approach known as 'rational drug design', targeting specific molecules based on a thorough understanding of the biology of a disease and the biochemical signals that support it.
Precise control of the distribution of specific proteins is essential for many biological processes. Researchers have now described a new model for intracellular pattern formation. Here, the shape of the cell itself plays a major role.
Scientists have achieved critical insight into the size of neural connections, putting the memory capacity of the brain far higher than common estimates. The new work also answers a longstanding question as to how the brain is so energy efficient and could help engineers build computers that are incredibly powerful but also conserve energy.
Bioengineers and cognitive scientists have developed the first portable, 64-channel wearable brain activity monitoring system that's comparable to state-of-the-art equipment found in research laboratories.