Scientists have developed a new method to directly follow viral infections in living organisms. This method can make infected cells produce fluorescent proteins, which means that they light up and become easier to identify.
Cryo-electron microscopy (cryo-EM), a technique that studies samples at cryogenic temperatures, combined with state-of-the-art computational modeling, allowed researchers to visualize large transcription pre-initiation complexes (PIC) at near-atomic resolution.
Researchers have discovered that the reversion process does not always fully capture the way a cell's genome is folded up inside its nucleus. This folding configuration directly influences gene expression and therefore the functionality of the cell.