Oct 02, 2019 | |
Scientists improve pancreatic cancer diagnosis with multifunctional platinum nanoreactor(Nanowerk News) Metabolic analysis involves ongoing biological pathways and can be more distal than proteomic/genomic approaches to in vitro diagnostics (IVD). However, point-of-care (POC) metabolic analysis needs special designed materials to detect target biomarkers of low concentration in complex biosystems. |
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Scientists from Shanghai Jiao Tong University, University of Surrey and the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) have developed a multifunctional platinum (Pt) nanoreactor geared towards POC metabolic analysis that performs visual detection and mass spectrometry (MS) fingerprinting simultaneously. | |
Their findings were published in Matter ("A Multifunctional Platinum Nanoreactor for Point-of-Care Metabolic Analysis"). | |
The Pt nanoreactor was designed with a controlled core-shell structure and morphology for the visual detection of metabolic biomarkers and direct laser desorption/ionization MS fingerprinting of the native serum. The molecular mechanism of efficient catalytic processes only takes 5 min for visual quantitation of metabolic biomarkers was also investigated. | |
In particular, the platform enabled biopsy-free diagnosis of pancreatic cancer patients with a sensitivity of 84% and specificity of 92%. | |
The scientists further identified a potential panel of five biomarkers, which may shed light on progression monitoring in response to therapy. | |
"It is a minimally invasive, high throughput and fast platform, improving accessibility to disease diagnosis," said Prof. QIAN Kun. | |
"This development of on-site and on-time diagnostics based on these nanoreactors may enhance the performance of POC devices geared towards personalized medicine and diverse diseases in the near future," Prof. LIU Jian added. |
Source: Chinese Academy of Sciences | |
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