| Apr 23, 2012 |
Researchers solve 40-year-old Fourier Transform Mass Spectrometry phasing problem
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(Nanowerk News) Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry (FTMS) at no extra cost.
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Researchers in the University's Department of Chemistry have solved the 40-year-old phasing problem which allows plotting of spectra in absorption mode.
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This breakthrough can be used in all FTMS including FT-ICR, Orbitrap and FT-TOF instruments and will have applications in proteomics, petroleum analysis, metabolomics and pharmaceutical analysis among other fields.
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Professor Peter O'Connor, who co-developed the method, said: "We have vastly improved the quality of data available at no extra cost.
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"FTMS is used extensively in the fields of pharmaceuticals, healthcare, industry, natural resources and environmental management so this breakthrough represents a real step towards improving research across the board in these areas."
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The method is detailed in the study "Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra" published in the journal Analytical Chemistry.
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It is co-authored by Professor O'Connor, Yulin Qi, Mark Barrow and Huilin Li from the University of Warwick.
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