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Tracking DNA helps scientists trace origins of genetic errors

Scientists have shed light on how naturally occurring mutations can be introduced into our DNA. The study, which focuses on how DNA replicates every time a cell divides, helps to make clear previously unexplained patterns in how our DNA changes over time. It also provides new insight into how the human genome has been shaped throughout evolution.

Jan 27th, 2015

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Researchers image and measure tubulin transport in cilia (w/video)

Defective cilia can lead to a host of diseases and conditions in the human body - from rare, inherited bone malformations to blindness, male infertility, kidney disease and obesity. A new study from University of Georgia cellular biologists shows the mechanism behind tubulin transport and its assembly into cilia, including the first video imagery of the process.

Jan 26th, 2015

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Research shows relationship critical for how cells ingest matter

To survive and fulfill their biological functions, cells need to take in material from their environment. In this process, proteins within the cell pull inward on its membrane, forming a pit that eventually encapsulates the material in a bubble called a vesicle. Researchers have now revealed a relationship that governs this process, known as endocytosis.

Jan 26th, 2015

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From stem cell to nerve cell in a few weeks

Scientists have developed a novel method for studying processes in the living brain, enabling them to observe how human stem cells transplanted into the cerebral cortex of mice develop into mature functional nerve cells.

Jan 22nd, 2015

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Mathematics improve single-cell analysis

A new computational approach allows to account for confounding factors and hidden biological processes in the analysis of single-cell RNA sequence data. Using this method, individual subpopulations and cell types can be identified within heterogeneous cell populations and can be determined more precisely.

Jan 21st, 2015

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Paving a road toward mitochondrial plant cell factories

Scientists have devised a new strategy for selectively delivering genes into the mitochondria of plant cells by using a simple combination of cell-penetrating and mitochondria-targeting peptides. This work lays the groundwork for the rational design of peptide-based gene carriers with the potential to create a new field of 'mitochondria engineering', which could enable the creation of mitochondria-based plant cell factories for the creation of bio-polymers and bio-fuels.

Jan 16th, 2015

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Damaged DNA amplified

Researchers have succeeded for the first time in amplifying gene samples containing DNA adducts while retaining references to these adducts. This type of amplification is a prerequisite for the majority of technologies used by researchers to determine a gene's DNA sequence.

Jan 15th, 2015

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