An Interagency Working Group on Manufacturing Research and Development established by the National Science and Technology Council has identified three technology areas as key research and development priorities for future manufacturing: Manufacturing for Hydrogen Technologies; Nanomanufacturing; and Intelligent and Integrated Manufacturing. The Working Group summarized their findings in a new report titled 'Manufacturing the Future.' Although this report is specific to the U.S., most of its general conclusions and recommendations apply to most other industrialized nations and their industrial nanotechnology efforts as well. Nanotechnology is viewed throughout the world as a critical driver of future economic growth and as a means to addressing some of humanity's most vexing challenges. Because of its broad range of prospective uses, nanotechnology has the potential to impact virtually every industry, from aerospace and energy to healthcare and agriculture. Nanomanufacturing integrates science and engineering knowledge and develops new processes and systems to assure quality nanomaterials, to control the assembly of molecular-scale elements, and to predictably incorporate nanoscale elements into nano-, micro-, and macroscale products utilizing new design methods and tools. Efforts in this area are directed toward enabling the mass production of reliable and affordable nanoscale materials, structures, devices, and systems. Nanomanufacturing includes the integration of ultra-miniaturized top-down processes and evolving bottom-up or self-assembly processes.
A key challenge in nano-optics is to bring light to and collect light from nano-scale systems. In conventional electronics, the interconnect between locally stored and radiated signals, for example radio broadcasts, is formed by antennas. For an antenna to work at the wavelength of light it needs to be greatly scaled down, to the nanoscale. Antennas play a key role in our modern wireless society. The electromagnetic waves sent and received by antennas are the messages that enable communication between electronics. Antennas with a wide variety of sizes make it possible for us receive radio broadcasts, watch television and talk to others on a mobile phone. For an effective communication, the antenna needs to direct signals towards their intended target and, vice versa, collect signals from a desired source. Now, researchers have shown that the concept of an antenna is equally well applied to direct the visible light sent out by a single molecule. For an antenna to work with visible light, it needs to be millions of times smaller than a conventional antenna. In this case, it is only 80 nanometer long. By placing the antenna near an individual molecule the light from that molecule is re-directed; the molecular message can be steered to a desired target, making efficient communication possible.
The success of the computer and communications industry is mainly due to the possibility of a large volume and low cost production output: silicon wafers containing myriad micro and nano structures are at the basis of Complementary Metal Oxide Semiconductor (CMOS) technology. A challenge is the realization of spatially ordered nanostructures in silicon that have many interesting applications like photonic crystals to mod the flow of light, chemical sensors, devices to alter the wetting of liquids on a surface, and as capacitors in high-frequency electronics used in mobile phones. The incorporation of such structures on existing silicon chips is greatly desired, and adapting conventional semiconductor nanofabrication to that end is widely pursued. Just a few days ago we wrote about the general aspects and challenges of silicon photonics and today we are taking a look at a specific fabrication challenge. The challenge for researchers is to to obtain photonic crystals with stop bands in the telecommunication wavelength regions, i.e.1330 nm and 1550 nm. To do that, the diameter of these pores must be smaller than 500 nm. The pore to pore distances, also referred to as pitch or interpore distance, must be well below 1 micrometer. Furthermore the depth to diameter aspect ratio of the pores must be as high as possible to obtain photonic crystals with large enough volumes. Researchers in The Netherlands now have demonstrated a method to etch arrays of nanopores in silicon with record depth-to-diameter ratios. These structures are suitable for nanophotonics and were made completely with CMOS compatible technologies, making integration of photonic structures in silicon chips feasible.
Polymethylmethacrylate (PMMA), a clear plastic, is a pretty versatile material. Plexiglas windows are made from PMMA. Acrylic paints contain PMMA. It also remains one of the most enduring materials in orthopedic surgery where it has a central role in the success of total joint replacement. Being part of a group of medical materials called 'bone cement', its use includes the fixation of biomaterials such as artificial joints to bone, the filling of bone defects and, also, as a drug-delivery system. Beginning in the 1970s, many successful results have been reported for total hip replacement using PMMA cement; however, failures of fixation have also occurred. The fixation strength of PMMA cement to bone is mainly dependent on mechanical interlocking, but it is known that a fibrous tissue layer intervenes between cement and bone - PMMA cement never bonds directly to the bone. One of the problems associated with the conventional types of bone cement used is their unsatisfactory mechanical and exothermic reaction properties. Other problems with PMMA cement include the biological response, leakage of the monomer of methylmethacrylate and a high curing temperature, which can damage cell activity. Ideally, a bone cement material must functionally match the mechanical behavior of the tissue to be replaced, it must be able to form a stable interface with the surrounding natural tissue and be effective in guided tissue regenerative procedures, it should be easy to handle, biologically compatible, non-supporting of microbial growth, and non-allergenic. A novel nanocomposite of carbon-nanotube-reinforced PMMA/HA is a demonstration of how nanomaterials will play an increasing role in the synthesis of next-generation biomedical applications.
In our Nanowerk Spotlights we usually stay with both feet firmly on the grounds of science and shy away from the science fiction and sensationalist aspects of nanotechnology. So today's headline might come as a surprise to you (but just to be safe we put a question mark in). Of course, there are no nanobots yet, and won't be for a while, but one of the fundamental problems to be solved for possible future molecular machinery is the challenge of controlling many molecule-sized machines simultaneously to perform a desired task. Simple nanoscale motors have been realized over the past few years but these are systems that do nothing more than generate physical motion of their components at a nanoscale level. To build a true nanorobot - a completely self-contained electronic, electric, or mechanical device to do such activities as manufacturing at the nanoscale - many breakthrough advances will need to be achieved. One of them is the issue of controlling large numbers of devices, i.e. how to build and program the 'brains' of these machines. Another issue is to separate the concept of science fiction style 'thinking' robots (artificial intelligence) from a more realistic (yet still distant) concept of machines that can be programmed to perform a limited task in a more or less autonomous way for a period of time. These tasks could range from fabricating nanoscale components to performing medical procedures inside the body. For nanoscale machinery this would require the availability of nanoscale control units, i.e. computers. Researchers in Japan are now reporting a self organizing 16-bit parallel processing molecular assembly that brings us a step closer to building such a nanoscale processor.
The past few years have seen tremendous progress in developing and fine-tuning fabrication methods for nanoparticles. An important research direction in nanoparticle synthesis is the expansion from single-component nanoparticles to hybrid nanostructures that possess two or more functional properties thanks to the integration of different materials. Multifunctional nanocarriers are a particularly hot topic in nanomedicine where it is hoped that such particles can significantly enhance the efficacy of many therapeutic and diagnostic protocols. What makes hybrid multicomponent nanostructures so alluring is not only the combination of different functionalities, but also the possibility to independently optimize the dimension and material parameters of the individual components. Apart from their multifunctionality, another advantage of these structures is that they can provide novel functions not available in single-component materials. A recent feature article provides an overview of the synthetic efforts of multicomponent hybrid nanoparticles via high-temperature solution-phase synthesis. The topics include chemical synthesis of multicomponent nanoparticles; characterization of the structural and physical properties, especially the ones arising from the interactions between different components; and potential applications of these multicomponent hybrid nanoparticles.
Understanding and manipulating cellular function at the level of individual molecules is within reach. One of the requirements of single molecule techniques is the ability to follow an individual molecule for sufficiently long times in solution. However, it is a challenge to cope with the effects of Brownian motion (the random motion of small particles suspended in a gas or liquid) on this time scale. To meet this challenge, more recently, biomolecules have been encapsulated inside lipid vesicles, which are themselves tethered to a surface. Now, a novel nanocontainer offers controlled permeability functionality which not only is desirable for single molecule imaging but also is a very important property for micro- and nanodevices and for delivery of drugs or imaging agents in vitro and in vivo.
The U.S. Food and Drug Administration has published a handbook called the Bad Bug Book which provides basic facts regarding foodborne pathogenic microorganisms and natural toxins. It contains all you always wanted to know about Salmonella, E. coli, parasitic protozoa, worms, viruses and natural toxins and other stuff that, when it gets in your hamburger, as it does from time to time, can make you pretty sick. It can even kill you. The Centers for Disease Control and Prevention (CDC) keep some pretty scary statistics and estimate that foodborne pathogens cause approximately 76 million illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States each year. Three pathogens, Salmonella, Listeria, and Toxoplasma, are responsible for 1,500 deaths each year. Salmonella is the most common cause of foodborne deaths and responsible for millions of cases of foodborne illness a year. Sources are raw and undercooked eggs, undercooked poultry and meat, dairy products, seafood, fruits and vegetables - so basically more or less everything you eat. Early detection of foodborne pathogenic bacteria, especially Salmonella, is therefore an important task in microbiological analysis to control food safety. Several methods have been developed in order to detect this pathogen; however, the biggest challenges remain detection speed and sensitivity. A novel nanotechnology-based biosensor is showing great potential for foodborne pathogenic bacteria detection with high accuracy.