Oral cancer represents one of the most dreadful killer diseases globally. Researchers have developed nano-sized layer by layer (LbL) assembled polyelectrolytes onto calcium carbonate particles to deliver small molecule tyrosine kinase inhibitors to human oral cancer cells. Calcium carbonate is a naturally occurring inorganic mineral with a porous structure generates a large surface area. It is biocompatible, biodegradable, acts as a sacrificial core template, and offers the opportunity to capture effectively a myriad molecules of interest like drugs, proteins, enzymes, etc. The researchers encapsulated sorafenib - a tyrosine kinase inhibitor - in CaCO3 nanoparticles, which was layered alternatively with biodegradable polyelectrolytes to form a multilayer shell.
Researchers have developed a highly manufacturable integration strategy for making 3D flexible sensor arrays and connecting them to control electronics based on the widely popular phrase, 'Two sides of the same coin'. Sensor arrays and control elements for flexible electronics devices are usually placed on the same plane, unnecessary requiring additional area, and causing problems of heat dissipation. These challenges motivated researchers to come up with an area-efficient solution for the problem of connecting sensors and electronics together in such a way that electronics can be kept away from the sensed surface. This is the first time ever the concept of double sided flexible 3D electronics has been introduced in the flexible and wearable electronics industry.
A major challenge in nanotechnology is that of determining how to introduce green and sustainable principles when assembling individual nanoscale elements to create working devices. For instance, textile nanofinishing is restricted by the many constraints of traditional pad-dry-cure processes, such as use of costly chemical precursors to produce nanoparticles, high liquid and energy consumption, production of harmful liquid wastes, and multistep batch operations. By integrating low-cost, scalable, and environmentally benign aerosol processes, these constraints can be circumvented while leading to a new class of multifunctional fabrics.
The serious threat of particulate matter (PM) air pollution to human health spurs development of advanced filter technologies. Particular efforts have been made in designing air filters with both high filtration efficiency and low airflow resistance by utilizing carbon nanotubes and electrospun polymer and inorganic nanofibers. In new work, scientists explored the performance of electrospun silk nanofiber membranes as air filters, which showed both of lightweight and high efficient features.
Newly developed nanocomposites possess efficient photothermic properties for highly targeted interfacial phase transition reactions that are synergistically favorable for seawater catalysis and desalination. The nanocomposites are seawater and photostable for practical solar conversion of seawater to simultaneously produce clean energy and water. This work defines the forefront of plasmonic photothermic technology, which is vastly untapped and has broad implications in other fields.
A theory analysis of energy / momentum conservation laws in a spatially confined coupled system of nearly free electrons and phonons hints that the absorption of electromagnetic waves by a metallic nano-object hosting longitudinal vibration modes may allow channeling the absorbed energy either into heat or into terahertz radiation, depending on the nano-objects? shape and size. This offers an explanation for the size selectivity of small nanoparticles in radio frequency hyperthermia, and suggests design for novel terahertz radiation sources.
Although developed only recently, inorganic halide perovskite quantum dot systems have exhibited comparable and even better performances than traditional quantum dots in many fields. They are expected to be applied in display and lighting technologies. Researchers now have reported an interesting cyclable surface dissolution and recrystallization phenomenon of inorganic perovskite crystals. This allows them to freely change size between nanometer and micrometer scales, and can be used to healing the defects inside perovskite films and hence improve the performances of optoelectronic devices.
Studies show hat mitochondrial metabolism theoretically is a plausible target for cancer therapy. Mitochondria are the primary controllers of cellular suicide; however, cancer cells trick this normal cellular mechanism and evade this process leading to uncontrolled cellular growth. To trigger the suicide switch back on, new work uses a highly selective nanotechnology-based approach to deliver a widely available small molecule commonly found as a by-product of a water chlorination process.