Proteins are the most important molecules inside our body. There are thousands of proteins in a single cell alone and they control our physiological reactions, metabolism, cellular information flow, defense mechanisms - pretty much everything. No wonder then that most human diseases are related to the malfunctioning of particular proteins. In contrast to gene therapy - where a gene is placed inside a cell to either replace a defective gene or to increase the amount of a specific gene in order to produce a higher amount of a desired protein - protein therapy works by directly delivering well-defined and precisely structured proteins into the cell to replace the dysfunctional protein. The problem with protein therapy, which limits its practical use in medicine, is the mode of delivery. Scientists have now demonstrated a general, effective, low-toxicity intracellular protein delivery system based on single-protein nanocapsules.
As the fields of bionanotechnologies develop, it will become possible one day to use biological nanodevices such as nanorobots for in situ and real-time in vivo diagnosis and therapeutic intervention of specific targets. A prerequisite for designing and constructing wireless biological nanorobots is the availability of an electrical source which can be made continuously available in the operational biological environment (i.e. the human body). Several possible sources - temperature displacement, kinetic energy derived from blood flow, and chemical energy released from biological motors inside the body - have been designed to provide the electrical sources that can reliably operate in body. Researchers now report the construction of a 980-nm laser-driven photovoltaic cell that can provide a sufficient power output even when covered by thick biological tissue layers.
Metastasis is caused by marauding tumor cells that break off from the primary tumor site and ride in the bloodstream to set up colonies in other parts of the body. These breakaway cancer cells in the peripheral blood are known as circulating tumor cells (CTCs). Detecting and analyzing these cells can provide critical information for managing the spread of cancer and monitoring the effectiveness of therapies. Nanotechnology researchers have now developed a an efficient cell-capture platform based on 3D nanostructured substrates. The device is engineered out of nanoscale silicon pillars and has managed to capture up to 65 percent of circulating tumor cells in lab samples within human blood - far more than any existing diagnosis tool for CTC capture.
Quite a number of serious medical conditions, such as cancer, diabetes and chronic pain, require medications that cannot be taken orally, but must be dosed intermittently, on an as-needed basis, and over a long period of time. By combining magnetism with nanotechnology, researchers have now created a small implantable device that encapsulates the drug in a specially engineered membrane, embedded with magnetic iron oxide nanoparticles. The application of an external, alternating magnetic field heats the magnetic nanoparticles, causing the gels in the membrane to warm and temporarily collapse. This collapse opens up pores that allow the drug to pass through and into the body. When the magnetic field is turned off, the membranes cool and the gels re-expand, closing the pores and halting drug delivery. No implanted electronics are required.
One of the promises of medical nanotechnology is a drug-delivery nanodevice that can image, target, and deliver drugs to a specific cancer location inside the body and monitor and if necessary adjust the drug release at the target location. Researchers in Taiwan have now designed a nanodevice that comes pretty close to this vision. They have successfully demonstrated that our multifunctional drug-delivery nanodevice - a polymer core/single-crystal iron oxide shell nanostructure bonded to a quantum dot - can image, target, and deliver drugs via remote control. The device shows outstanding release and retention characteristics via an external on/off manipulation of a high-frequency magnetic field. Furthermore, the quantum dot bonded to the nanodevice provides optical information for in situ monitoring of the drug release.
Detection at the earliest stage provides the greatest chance of survival for cancer patients. Cancer has a logarithmic growth rate and doctors typically don't see 80% of the life of a tumor. Detection can be done using a number of techniques including standard immunoassays and biopsies. Nanotechnology offers new detection approaches such as targeted contrast agents, nanoscale cantilevers coated with antibodies against tumor markers, and magnetic nanoparticles coated with DNA labeling. But the problem is daunting because there are over 50 common types of cancer and in practice it is difficult to ask people to come to the clinic on a regular basis for cancer screening. Researchers have now proposed a new method for the detection of cancer cells based on measurement of the physical adhesion of silica beads to malignant versus normal cells cultured from human cervix.
In animal cells, the well known cytoskeletal proteins actin microfilaments and microtubules are accompanied by a third filament system that in humans consist of a family of more than 70 proteins. These fibrous proteins are absent from both plants and fungi, and have been linked to serious human diseases including cancer, muscle dystrophies and rapid aging disease. Their name, intermediate filament, was coined back in 1978 because their diameters - about 10 nanometers - appeared to be intermediate in size between those of microtubules and microfilaments. Their atomistic-level molecular structure remains elusive, and as a consequence, the understanding of the biological role in physiological and disease states is still in its infancy. Researchers now report a breakthrough in explaining the structural and mechanistic origin of the unique mechanical properties of intermediate filaments. By combining atomistic and molecular modeling with experimental studies, the researchers report a multi-scale analysis that showed that the mechanical properties of intermediate filaments are controlled by their characteristic hierarchical makeup.
Here is a no-brainer (excuse the pun): If you had brain tumor, would you rather receive your medicine through an injection in the arm or have a hole drilled in your skull? Even if you opted for the 'hole-in-the-skull' method, brain cancers are often inoperable due to their location within critical brain regions or because they are too small to detect. Nanotechnology offers a vision for a smart drug approach to fighting tumors: the ability of nanoparticles to locate cancer cells and destroy them with single-cell precision. One of the most important applications for such nanoparticulate drug delivery could be the delivery of the drug payload into the brain. However, crossing the brains protective shield, the blood-brain barrier, is a considerable challenge. Novel targeted nanomedicine drug delivery systems that are able to cross this barrier bring us closer to this vision of brain cancer destroying drugs.