Neural interfaces establish direct communication between the central nervous system (CNS) and a sovereign, man-made digital system. This technology is perhaps the most important advance in the study and treatment of the brain is the development of the neural interface. Nanotechnology fabrication methods can overcome the limitations of existing interface devices by producing electrodes with an extremely high surface to volume ratio, i.e., more probe units within the same volume, resulting in unprecedented specificity.
Given the growing impact of nanotechnology on health care, pharmacy, and medicine, there is an increasing and urgent need for the development of reliable methods applicable to detect the biological contamination of nanoparticles. A new method offers a solution to the problems of the nanoparticle interference and correct quantification of bio-contaminants such as endotoxins. This proposed method is based on optical absorbance measurements.
Cutaneous fungal infections involving the skin, hair, or nails affect an estimated 25% of the world's population, and accounts for millions of outpatient visits. Currently, deep fungal infection require systemic therapy, which can pose a range of side effects or drug interactions depending on the clinical scenario. Investigators now have demonstrated the antifungal activity of nitric oxide generating nanoparticles against dermatophytes well known to cause invasive cutaneous infections.
With their special structure and large surface area, MOFs open up new opportunities in drug delivery. The ability to exchange the metal centers and organic linkers even provide an extensive library of MOF materials. As a result, the integration of small guest molecules within the MOF pores, such as small molecule drugs and biomolecules, have shown promise for delivery applications to treat diseases. A recent review article discusses current proceedings on integrating diverse biomolecules within MOFs.
A look at the emerging roles of nanotechnology in the rapidly evolving domain of modern/future radiation therapy. In an effort to devise novel and more effective anticancer regimes, a rapidly growing community of researchers is applying the unique properties of nanomaterials to combat the unmet challenges posed by classical radiation therapy - which has become one of the most effective and frequently applied cancer therapies. However, despite a plethora of preclinical studies, nanoparticle mediated combination RT/phototherapy has not yet been translated in the clinic.
Dendrimers have emerged as a powerful class of nanomaterials in nanomedicine due to their unique structural features: globular, well-defined, highly branched and controllable nanostructures where the presence of several terminal groups can be functionalized with different ligands simulating the multivalency present in different biological systems. A recent review article identifies the currently existing dendritic systems and discusses their strengths and caveats in the context of attaining efficient therapeutic strategies for the treatment of neurological disorders.
Nanotechnology is becoming a crucial driving force behind innovation in medicine and healthcare, with a range of advances including nanoscale therapeutics, biosensors, implantable devices, drug delivery systems, and imaging technologies. This article provides a comprehensive overview of healthcare advances that may be possible through nanotechnology, ranging from fitness monitoring, prevention, diagnosis to therapy, and everything in between.
Inspired by octopus arms, researchers demonstrate an uncomplicated and scalable templating technology for fabricating nanosuckers on PDMS substrates, using a scalable spin-coating technology. As the nanosuckers are pressed against a substrate, the flexible nanosuckers confirm to the substrate and deform by releasing the internal air between nanosuckers and the substrate, forming a seal and generating an adhesion force. The nanosucker adhesion is maintained over multiple contact cycles on both wet and dry surfaces.