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Nanotechnology Spotlight

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Showing Spotlights 9 - 16 of 351 in category Bionanotechnology, Nanomedicine (newest first):


Smart materials become 'alive' with living bacteria in supramolecular assemblies

modified_bacteriaSupramolecular chemistry deals with molecular building-blocks that interact with each other in a dynamic manner, similar to what is seen in nature. Taking advantage of this, several 'smart' materials have been developed for biomedical applications by careful design of these building-blocks. These materials have especially interesting properties like self-healing and responsiveness to light and electricity. Researchers have now explored the possibility of developing a bacterial strain with the ability to interact dynamically with a popular supramolecular building-block.

Posted: Mar 26th, 2015

A quick and simple blood test to detect early-stage cancer

protein_coronaA novel nanoparticle blood test detects an overall increase of human immunoglobulin G (IgG), including the tumor-specific autoantibodies, adsorbed to a gold nanoparticle surface. While this test may not be able to identify the specific type of cancer, it may potentially be able to detect early stage tumor-induced immune responses associated with a broad spectrum of cancer types, making this test potentially a universal screening test for cancer risk assessment.

Posted: Mar 24th, 2015

Nanoparticle shape can drastically enhance MRI signals

nanostarsTypically, in clinical formulations of Magnetic Resonance Imaging (MRI) contrast agents, gram quantities of Gd(III) are needed to achieve sufficiently high contrast for examination. That's why the research imaging community is interested in developing new formulations of contrast agents able to bridge the gap between high contrast imaging of contrast agents dosed at low concentrations. In new work, researchers report a new class of gold nanoconjugates that exhibit exceptionally high relaxivities at both low and high field strengths.

Posted: Mar 23rd, 2015

Nanotechnology to the rescue: Replacing chemical disinfectants with engineered water nanostructures

water_nanostructureTrying to develop chemical free disinfection techniques, researchers are currently exploring the effectiveness of a nanotechnology based intervention method for the inactivation of foodborne and spoilage microorganisms on fresh produce and on food production surfaces. This method utilizes Engineered Water Nanostructures (EWNS) generated by electrospraying of water. These EWNS are 25 nm in diameter; remain airborne in indoor conditions for hours; contain Reactive Oxygen Species (ROS); have very strong surface charge (on average 10 electrons per structure) and have the ability to interact and inactivate pathogens by destroying their membrane.

Posted: Mar 16th, 2015

One-step detection of pathogens and viruses with high sensitivity

bacteriumResearchers have developed a magnetic bead based sensor that combines magnetic separation (MS) and magnetic relaxation switch (MRS) for one-step detection of bacteria and viruses with high sensitivity and reproducibility. Compared to conventional assays for detection of bacteria and viruses, this novel MS-MRS assay is easy to operate without laborious pre-treatment, purification and can be adaptable to point-of-care tests easily.

Posted: Mar 13th, 2015

Has nanomedicine lived up to its promise?

nanomedicineHistorically, the approval of Doxil as the very first nanotherapeutic product in 1995 is generally regarded as the dawn of nanomedicine for human use. Although numerous products classified as nanomedicine products have indeed appeared over the past decade, such products have not exactly revolutionized treatment paradigms as envisaged earlier. In particular no molecular machine or nanorobot has yet entered clinical trials, although research in these areas is picking up pace.

Posted: Mar 10th, 2015

Plasmonic nanocrystals for combined photothermal and photodynamic cancer therapies

hyperthermiaAn international team of researchers used abiotic assays, cultured cancer cells, and a melanoma animal model to demonstrate the photothermal therapy (PTT) activity of copper sulfide nanocrystals. The research lays out the working principle of colloidal, near-infrared light (NIR) plasmonic copper sulfide nanocrystals exploitable for both photodynamic therapy (PDT) and PTT therapy with NIR activation. This is the first report that under a NIR light radiation copper sulfide nanocrystals achieve efficient cancer destroying efficacy via PTT and PDT mechanisms both in vitro and in vivo.

Posted: Feb 17th, 2015

Multiplexing biosensors on a chip for human metabolite detection

hydrogelSo far, there have been very few research reports on single electrode materials that enable the simultaneous detection of different metabolites - such as glucose, urea, cholesterol, and triglycerides - in whole blood. Moreover, it is a considerable challenge to integrate all required materials and devices on a single chip to ultimately produce a multiplexing biosensor array. In new work, researchers demonstrate that biosensors based on conducting polymer hydrogels enable the precise and full-range detection of different metabolites in human blood.

Posted: Jan 22nd, 2015