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Easy recipe to make bone and cartilage

The repair of large bone defects and damaged cartilage remains a significant clinical challenge, with current strategies unable to reliably generate the cells that make bone and cartilage. Now, researchers are able to produce such cells by exposing embryonic stem cells to a combination of small molecules, mimicking normal development. This strategy is easily scalable, offering great potential in bone and cartilage regenerative medicine.

Oct 7th, 2014

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A new way to extract bone-making cells from fat tissue

By sorting human fat tissue cells by their expression of a certain gene, scientists were able to retrieve a high yield of cells that showed an especially strong propensity to make bone tissue. With more refinement, the method could improve the ability of surgeons to speed bone healing.

Oct 6th, 2014

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Scientists develop barcoding tool for stem cells

A seven-year-project to develop a barcoding and tracking system for tissue stem cells has revealed previously unrecognized features of normal blood production: new data suggests, surprisingly, that the billions of blood cells that we produce each day are made not by blood stem cells, but rather their less pluripotent descendants, called progenitor cells.

Oct 5th, 2014

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'Programmable' antibiotic harnesses an enzyme to attack drug-resistant microbes

Conventional antibiotics are indiscriminate about what they kill, a trait that can lead to complications for patients and can contribute to the growing problems of antibiotic resistance. But a a 'programmable' antibiotic being developed at Rockefeller would selectively target only the bad bugs, particularly those harboring antibiotic resistance genes, and leave beneficial microbes alone.

Oct 5th, 2014

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RCas9: A programmable RNA editing tool

A powerful scientific tool for editing the DNA instructions in a genome can now also be applied to RNA as researchers have demonstrated a means by which the CRISPR/Cas9 protein complex can be programmed to recognize and cleave RNA at sequence-specific target sites.

Oct 3rd, 2014

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High-throughput cell-sorting method can separate 10 billion bacterial cells in 30 minutes

A mechanical engineer has developed a new, high-throughput method for sorting cells capable of separating 10 billion bacterial cells in 30 minutes. The finding has already proven useful for studying bacterial cells and microalgae, and could one day have direct applications for biomedical research and environmental science - basically any field in which a large quantity of microbial samples need to be processed.

Sep 26th, 2014

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DARPA awards $7.9M to build an artificial immune system

Scientists from both campuses of The Scripps Research Institute (TSRI) have been awarded a total of $7.9 million from the Defense Advanced Research Projects Agency (DARPA). The two teams will build what is, in essence, an artificial immune system, comprising vast 'libraries' of different types of molecules from which will emerge individual compounds to detect or neutralize an array of biological and chemical threats.

Sep 24th, 2014

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