Showing Spotlights 25 - 29 of 29 in category All (newest first):
Hands-on nanotechnology: towards a nanorobotic assembly line
(Nanowerk Spotlight) Until the twentieth century, a single craftsman or team of craftsmen would normally create each part of an industrial product individually and assemble them together into a single item, making changes in the parts so that they would fit together and work together; the so-called English System of manufacture. Then Henry Ford came along and in 1907-08 developed the assembly line for his Model T automobile. This innovation revolutionized not only industry but also our society because it allowed mass production of industrial goods at much lower cost than before. At its core, an assembly line is a manufacturing process in which interchangeable parts are added to a product in a sequential manner to create a finished product. Nanotechnology techniques today are pretty much where the industrial world was before Ford's assembly line - a domain of craftsmen and not of mass production. It has long been a dream for nanotechnologists that robots could one day be used in a similar way to produce nanodevices. A group of researchers from Denmark and Germany have now developed the rudimentary beginnings of the nanotechnology equivalent of an assembly line. They have shown 'pick-and-place' assembly of a working device using a silicon gripper - a robotic 'hand' some 10000 times smaller than a human hand. This nanogripper, controlled by a nanorobotic arm, is capable of picking up a carbon nanofiber (CN) and fix it onto the tip of an atomic force microscope cantilever.
Sep 11th, 2007
Vaccination has resulted in the eradication of smallpox and control of measles, rubella, tetanus, diphtheria, and other infectious diseases in many areas of the world (at least where vaccines are available and affordable; providing vaccines to many parts of the developing world still is one of the basic medical needs that is far from being met). The basic idea of vaccination (the word comes from the Latin vacca - cow - because the first vaccine was derived from a virus affecting cows) is to inject weakened or killed forms of pathogens such as bacteria or viruses into the body in order for the immune system to develop antibodies against them; if the same types of microorganisms enter the body again, they will be destroyed by the antibodies. About 25 years ago, the basic idea of vaccination gave rise to bactofection - the technique of using bacteria as non-viral gene carriers into target cells. The DNA cargo is transported inside the bacteria and, once it arrives at the target location, the bacteria is broken up in order to release the therapeutic gene or protein. A novel technique takes advantage of the invasive properties of bacteria for delivery of nanoparticles into cells. Here, the gene or cargo is not carried inside the bacteria, but rather remains on the surface conjugated to nanoparticles. Consequently, this approach does not require bacterial disruption for delivery, or any genetic engineering of the bacteria for different cargo.
Aug 14th, 2007
Science fiction style robots like Star Wars' R2-D2 or the NS-5 model in I, Robot firmly belong into the realm of Hollywood - and so do "nanobots" a la Michael Crichton's Prey. Staying with both feet firmly on scientific ground, robotics can be defined as the theory and application of robots, a completely self-contained electronic, electric, or mechanical device, to such activities as manufacturing. Scale that robot down to a few billionth of a meter and you are talking nanotechnology robotics; nanorobotics in short. The field of nanorobotics brings together several disciplines, including nanofabrication processes used for producing nanoscale robots, nanoactuators, nanosensors, and physical modeling at nanoscales. Nanorobotic manipulation technologies, including the assembly of nanometer-sized parts, the manipulation of biological cells or molecules, and the types of robots used to perform these tasks also form a component of nanorobotics. Nanorobotics might one day even lead to the holy grail of nanotechnology where automated and self-contained molecular assemblers not only are capable of building complex molecules but build copies of themselves - "self-replication" - or even complete everyday products (this vision is nicely illustrated in the clip "Productive Nanosystems: From Molecules to Superproducts"). Whether this will ever happen is hotly debated - to understand where both sides stand, read the famous 2003 debate where Drexler and Smalley make the case for and against molecular assemblers. Today's nanorobotics research deals with more mundane issues such as how to build nanoscale motors and simple nanomanipulators.
Apr 5th, 2007
It's not quite like in Isaac Asimov's science fiction classic Fantastic Voyage, where five people travel in a submarine inside a person's blood stream, but scientists have talked for quite some time about micro and nanorobotic devices that can travel inside the human body and carry out a host of complex medical procedures such as monitoring, drug delivery and cell repair. Recent developments in micro- and nanoscale engineering have led to realization of various miniature mobile robots. It turns out that the most significant bottleneck for further miniaturization of mobile robots down to micrometer scale is the miniaturization of the on-board actuators and power sources required for mobility. Nature has already provided remarkable solutions to this problem by evolving chemically powered molecular motors. Such biomotors seem to be one of the most promising choices for on-board actuation. They are advantageous over man-made actuators because they are much smaller in size and are capable of producing more complicated motions. More importantly, they convert chemical energy to mechanical energy very efficiently. However, the major drawback of biomotors is that isolating and reconstituting them are complicated tasks with low yield and it is difficult to interface them with electronic circuitry. This has led scientists to successfully experiment with a new approach by using flagellar motors (the propulsion system of bacteria), still inside the intact cells, as actuators.
Feb 16th, 2007
The success of nanorobotics requires the precise placement and subsequent operation of specific nanomechanical devices at particular locations, thereby leading to a diversity of structural states. The structural programmability of DNA makes it a particularly attractive system for nanorobotics. A large number of DNA-based nanomechanical devices have been described, controlled by a variety of methods. These include pH changes and the addition of other molecular components, such as small molecule effectors, proteins and DNA strands. The most versatile of these devices are those that are controlled by DNA strands. This versatility results because they can be addressed specifically by strands with particular sequences. Researchers at New York University have developed a framework that contains a binding site ‚?? a cassette ‚?? that allows insertion of a rotary device into a specific site of a DNA array, allowing for the motion of a nanorobotic arm. Changing the cassette‚??s control sequences or insertion sequences allows the researchers to manipulate the array or insert it at different locations.
Jan 10th, 2007