Scientists consider the exploration of carbon nanotubes (CNTs) for biomedical applications as a field with significant potential, leading to applications where CNTs could act as magnetic nano-heaters, drug-carrier systems and sensors which allow a diagnostic and therapeutic usage on a cellular level. The EU, for instance, has funded a four-year nanotechnology research program that studies the chemical and physical properties of CNTs in order to find mechanisms which can be applied for a biomedical purpose in appropriate medical devices. Studies of their interaction with biological environments (immune response, toxicity, interaction with the single cell) will provide the basis for applying the CNT for imaging (nanoparticles-based contrast agents), sensoring (nanoparticles-based diagnostics) and cancer treatment (hyperthermia, nanotechnology-based targeted drug delivery). A new study that exploits the unique properties of single-walled CNTs (SWCNT) for biomedical purposes shows the use of SWCNTs as an efficient platform for immunotherapeutic applications. Scientists demonstrate the surface area tunability of SWCNT bundles by chemical treatment and its effect on antibody adsorption and subsequent T cell activation. T cells are central players in initiating and maintaining immune responses. An important goal of successful immunotherapy is the stimulation of T cell immune responses against targets of interest such as tumors.
Cells are the basic building blocks of life. The ability to sense and modify intracellular processes is important for, among other things, bettering our understanding of biological processes, developing drugs and evaluating their effectiveness, and modifying cell function. Due to the cell's small size and fragility, probing the cell's interior with high precision is not a simple task. To address this challenge, researchers have developed nanoscale, carbon-based cellular probes ('carbon nanopipettes' or CNP). The CNP consists of a glass capillary lined with a carbon film along its inner surface and terminating with an exposed carbon nanopipe. The probes are fabricated through a process that does not require any assembly and that facilitates quantity fabrication. Depending on controllable process conditions, the carbon tip's diameter may vary from tens to hundreds of nanometers and its length can range from zero to a few micrometers.
In recent years, great progress has been made in the synthesis and application studies of hybrid nanomaterial systems involving carbon nanotubes (CNTs). Efforts involve the alteration of physical properties of CNTs via the use of organic, inorganic, and biological species to produce functionalized CNTs for further applications. In one such hybrid system, aligned CNT templates serve as a natural 3D scaffold ('CNT forests'). Preferential assembly of nanoparticles onto targeted locations in this 3D scaffold creates novel hybrid nanomaterial systems with a unique architecture comprised of different functional components. For example, these CNT forests could serve as a template for controlled assembly of various semiconducting nanoparticles such as quantum dots. The resulting hybrid nanomaterial has the effect of changing both optical and electronic properties of the CNTs.
Carbon nanotubes (CNTs) have been widely used as electrodes for chemical and biological sensing applications and many other electrochemical studies. With their unique one-dimensional molecular geometry of a large surface area coupled with their excellent electrical properties, CNTs have become important materials for the molecular engineering of electrode surfaces where the development of electrochemical devices with region-specific electron-transfer capabilities is of paramount importance. It has been demonstrated that carbon nanotubes enhance the electrochemical activity of biomolecules and promote the electron-transfer reactions of redox proteins, such as myoglobin, cyctochrome c, and microperoxidase MP-11. The enhanced electrochemical activity and electron transfer rate at CNT electrodes have been widely believed to arise from the nanotube tips. However, no convincing experimental evidence has been obtained to prove that the CNT tip is more electrochemically active than its sidewall. Contradicting this common belief, researchers have now found that, surprisingly, the electrochemistry at carbon nanotube electrodes is not always facilitated by the nanotube tip. In fact, the relative electrochemical sensitivity of the nanotube tip and sidewall varies for different electrochemical probes proceeding with different reaction mechanisms.
You might have seen our news item from a few days ago about BMW's shape shifting concept car. NASA has worked on something much more revolutionary, called the 'Morphing' program, for a few years already. The idea is that aircraft of the future will not be built of traditional, multiple, mechanically connected parts and systems. Instead, aircraft wing construction will employ fully-integrated, nanotechnology enabled embedded 'smart' materials and actuators that will enable aircraft wings with unprecedented levels of aerodynamic efficiencies and aircraft control. Able to respond to the constantly varying conditions of flight, sensors will act like the nerves in a bird's wing and will measure the pressure over the entire surface of the wing. The response to these measurements will direct actuators, which will function like the bird's wing muscles. Just as a bird instinctively uses different feathers on its wings to control its flight, the actuators will change the shape of the aircraft's wings to continually optimize flying conditions. Active flow control effectors will help mitigate adverse aircraft motions when turbulent air conditions are encountered.
Synthesized carbon nanotubes, especially single-walled carbon nanotubes (SWCNTs), are in the form of bundles with other impurities such as catalyst particles and amorphous carbon debris. In order to be useful for many types of applications, for instance in nanoelectronic devices or biomedical applications, SWCNTs need to be purified and dispersed into individual nanotubes. One method to do this is by surfactant stabilization of the hydrophobic nanotube surface, which overcomes the van der Waals forces among the nanotubes and results in suspensions of individual SWCNTs. Researchers have now investigated the cytotoxicity of SWCNTs suspended in various surfactants. Their experimental results show that the conjugates SDS/CNT and SDBS/CNT are toxic to astrocytoma cells due solely to the toxicity of the SDS and SDBS molecules, which administered alone are toxic to the cells even at a low concentration of 0.05 mg per ml within 30 min. However, the proliferation and viability of the astrocytoma cells were not affected by SWCNTs and the conjugates SC/CNT and DNA/CNT.
For a decade, researchers and industry professionals have been warning that the limits of silicon were quickly being approached. According to some, these limits have, effectively, already been reached. The age of the integrated microchip circuit - fabricated out of silicon - may be drawing to a close. But, is there any technology ready to fill the void? Is there any technology that could make circuits smaller or more powerful? They answer to this may very well be 'yes.' Although silicon holds numerous properties that make it a rather ideal conductor of electricity under certain conditions, it lacks one crucial characteristic, which may end-up making carbon the material of the future: The ability to form complex, tubular arrays on the scale of only a few nanometers. The age of the integrated nanochip circuit - made-up of composite carbon nanotubes - may have arrived.
Fuel cells have gained a lot of attention because they provide a potential solution to our addiction to fossil fuels. Energy production from oil, coal and gas is an extremely polluting, not to mention wasteful, process that consists of heat extraction from fuel by burning it, conversion of that heat to mechanical energy, and transformation of that mechanical energy into electrical energy. In contrast, fuel cells are electrochemical devices that convert a fuel's chemical energy directly to electrical energy with high efficiency and without combustion (although fuel cells operate similar to batteries, an important difference is that batteries store energy, while fuel cells can produce electricity continuously as long as fuel and air are supplied). Modern fuel cells have the potential to revolutionize transportation. One of the leading fuel cell technologies developed in particular for transportation applications is the proton exchange membrane fuel cell, also known as polymer electrolyte membrane fuel cells - both resulting in the same acronym PEMFC