The interest in exploring the use of noble metal nanoparticles for diagnostic and therapeutic imaging stems from the drawbacks of current in vivo probes. Fluorescent probes, such as fluorescent dyes and proteins, are not photostable and therefore are useful only for a limited time during the probing event. Besides imaging agents, especially gold nanoparticles are also intensely researched as target-specific vehicles for drug delivery. Due to its inert chemical properties, gold has been widely considered as one of the most stable and biocompatible materials. But studies of the biocompatibility and toxicity of gold nanoparticles in various types of cells have yielded inconclusive results: some studies show a toxic effect and high-dependence of toxicity on nanoparticle size and surface functional groups, while other studies report no significant cytotoxicity. Many of these studies did not use purified gold nanoparticles, or examine any other chemicals present in the gold nanoparticle solutions, or well characterize the physical properties, leading to these inconclusive results. Researchers have now synthesized and characterized stable, nearly monodisperse, and highly purified gold nanoparticles, and utilized them to study cleavage-stage embryos in real-time and to probe their effects on embryonic development at the single-nanoparticle level in real time.
The folks at the European NanoHand project, whose nanogripper design we have covered in a previous Nanowerk Spotlight, seem to have loved playing with their plastic toy kits as kids. At least that's the impression you get when watching their latest video explaining their proof-of-principle study of scanning probe tips defined by planar nanolithography and integrated with AFM probes using nanomanipulation. They have prefabricated nanoscale needles, to be picked up by nanogrippers inside a scanning electron microscope. They then use these nanobits as ultralong tips in atomic force microscopes. The researchers call the needles 'nanobits' because they are a reminder of drill bits - you can have a library of different nanobits and then pick the one you want, and mount it where you want it.
A few years ago it was discovered that the process of thermal inkjet printing can be applied to fabricate hard tissue scaffolds and, just recently, soft tissue with liquid biomaterials. Research is also underway to use inkjet printing for the fabrication of organic semiconductors, opening a route to the fabrication of high-performance and ultra low-cost electronics such as transparent electronics and thin film solar cells. As a matter of fact, the installation of the world's first silicon-ink based solar cell pilot production was completed this January. In your office, though, you have a choice between inkjet printers and (usually much faster) laser printers. And soon, nanotechnologists might have this choice, too. Researchers in California have demonstrated a novel technique for rapidly 'printing' various nanoparticles such as gold nanoparticles, carbon nanotubes, and semiconducting and metallic nanowires, on a photoconductive surface by light, much like a laser printer prints toner powder on paper.
Ferroelectric domain patterns attract increasing attention owing to their potential for integrated optical and novel electronic applications. Lately, Piezoresponse Force Microscopy (PFM) has become a standard technique for the investigation of such domain patterns due to the high lateral resolution of only about 10 nm even - so no specific sample preparation is needed. In addition, due to the frequency modulated PFM technique for recording ferroelectric domains, topography and domain patterns can be recorded simultaneously and independently. Piezoresponse force microscopy is based on the deformation of the sample due to the converse piezoelectric effect. Generally, all scanning force microscopes are suited for PFM operation as long as they allow application of voltages to the tip and separate readout of the cantilever movement.
There is no denying the fact that plastic wastes have caused serious environmental problems - and continue to do so. Everyday plastic products, for instance water bottles or plastic bags from supermarkets, are so durable that they will either not rot at all or have long biodegradation periods of 50 years and more. Although so-called 'biodegradable' plastic products typically contain chemicals that help them fragment, the additives do not render the plastic biodegradable. While it is important to develop various techniques for the elimination of plastic wastes - landfills, incineration etc. - these solutions typically present several disadvantages such as re-entering the environment and cause re-pollution, loss of natural resources, or depletion of landfill space. Researchers in China have now developed a technique that uses waste plastics as carbon source for synthesizing silicon carbide nanomaterials. This may actually provide an effective method to help solve the environmental pollution of waste plastics.
Humans have always tried to improve themselves through 'natural methods' such as physical exercise, diet, meditation, education and training. However, as a new report on human enhancement points out, with ongoing work to unravel the mysteries of our minds and bodies, coupled with the art and science of emerging technologies, we are near the start of the Human Enhancement Revolution. Technology will be a big game changer. While previously technological progress has improved the tools we work with, from the printing press to the steam engine to computers, in the future, technology will change ourselves, our bodies and, possibly, even our minds. A new addresses questions and issues surrounding human enhancement, an area that will become more prominent as advances in nanotechnology, nanomedicine, bionics, synthetic biology and related fields move from the lab to real-world applications.
Much of EPA's focus over the past several years has been aimed at filling information gaps and gathering more data regarding the potential risks associated with nanomaterials, mostly through voluntary programs and agency-funded research. Recently, EPA has moved to quicken the pace of its regulatory efforts, through a series of actions taken under the authority of the Toxic Substances Control Act (TSCA). The agency has also fired a clear shot across the bow of the nanotechnology industry, warning producers and importers of nanoscale materials that the agency intends to pursue enforcement actions against companies that fail to heed EPA's new focus on regulating nanomaterials under TSCA. In light of these developments, companies with an interest in nanotechnology may want to reexamine the agency's recent regulatory initiatives, in order to gain a better understanding of how those actions might affect them.
According to the World Health Organization, lung cancer is the leading cancer-related cause of death, accounting for 18 percent of cancer deaths and killing about 1.3 million people worldwide every year. Conventional diagnostic methods for lung cancer occasionally miss tumors and they are costly and unsuitable for widespread screening. Breath testing is a fast, non-invasive diagnostic method that links specific volatile organic compounds (VOCs) in exhaled breath to medical conditions. However, these techniques - gas chromatography/mass spectrometry, ion flow tube mass spectrometry, laser absorption spectrometry, infrared spectroscopy, polymer-coated surface acoustic wave sensors and coated quartz crystal microbalance sensors - are expensive, slow, and require complex instruments. A multidisciplinary research team at Technion - Israel Institute of Technology have now demonstrated a highly sensitive, stable, relatively inexpensive, and fast-response nine-sensor array that consists of gold nanoparticles functionalized with different organic groups that respond to various VOCs that are relevant to lung cancer.