Nanotechnology Spotlight – Latest Articles

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Showing Spotlights 9 - 16 of 30 in category Application Notes (newest first):


Ingenuity the key to a promising new oral influenza vaccine

vaccineMore serious than the common cold, influenza viral infection has been responsible for major epidemics and pandemic respiratory disease in communities around the world. These epidemics come with substantial morbidity and mortality, accounting for 250,000 to 500,000 worldwide deaths each year and are particularly dangerous for vulnerable and elderly populations with statistics showing that 90% of those who succumb to the severe illness are 65 years and older. The flu is also associated with high health care costs. In the U.S., more than $80 billion dollars is spent annually as a result of influenza epidemics.

Mar 3rd, 2014

Integrated optical and AFM metrology

AFM_metrologySurface metrology and characterization is ever more critical for overall product performance in wide ranging applications across the semi-conductor, LED, data storage, medical and automotive industries. 3D optical microscopes are among the fastest and most accurate imaging systems on the market today, and are employed in these industries for rapid and precise process monitoring, product development, and research. However, there are instances where they have performance limitations and the benefits of scanning probe/atomic force microscopy provide a clear advantage.

Feb 6th, 2014

Ingenuity attracts attention with biomining advances

functionlized_nanoparticleIngenuity Lab in Edmonton, Alberta are taking cues from nature, as they focus on nanotechnology gains in the area of biomining. Using microorganisms and biomolecules, the group is making significant advances in the recovery of rare earth and precious metals from industrial processes and the environment thanks to superior molecular recognition techniques. The researchers at Alberta's first nanotechnology accelerator laboratory are looking to take advantage of inorganic binding peptides for mining valuable and rare earth elements/metals that exist in nature or synthetic materials.

Feb 3rd, 2014

Toward quantitative nanomechanical measurements on live cells

plant_cellMeasuring and mapping mechanical properties of live cells is of high importance in today's biological research. raditionally, force spectroscopy and force volume are the most commonly used modes to quantitatively measure mechanical forces at the nanometer scale. Unfortunately, both techniques have suffered from slow acquisition speed and a lack of automated tools to analyze the hundreds to thousands of curves required for good statistics. This application note reviews recent progress in mapping the properties of soft samples such as cells and gels with force volume and PeakForce QNM and the use of the newest NanoScope and NanoScope Analysis features to collect and analyze the data from these techniques.

Dec 30th, 2013

Anti-counterfeiting with DNA nanotechnology

dna_securityRecent developments in nanotechnology have enabled significant improvement in the field of anti-counterfeiting measures. One company for instance is working on fluorescent nanostructures to improve banknote security; another one has developed DNA tags for deposition on nanoelectronics wafers and computer chips to ensure the integrity and security of processed wafers. DNA-based protection technologies are especially suitable for anti-counterfeiting measures.The DNA molecules are added a products raw material during the production process. Only 1 ppm (one part per million) is required to uniquely mark the material The DNA molecular structure can then be read as a mathematical code based on the four DNA molecules. So a DNA code, in contrast to the binary code used in IT security, is a combination of the letters A, C, G and T. A 10-digit code could look like this: C-G-A-C-T-T-G-A-C-A.

Nov 6th, 2012

Gold nuggets for biotechnology: Introducing laser-generated nanoparticle conjugates

gold_nanoparticleBio-conjugated nanoparticles are important analytical tools with emerging biological and medical applications. Especially gold nanoparticles are of increasing interest for nanobiotechnology research and applications because of their high acceptance level in living systems and the fact that they are fairly easily conjugated with functional molecules. Ultrashort pulsed laser ablation represents a powerful tool for the generation of pure gold nanoparticles avoiding chemical precursors, reducing agents, and stabilizing ligands. The bare surface of the charged nanoparticles makes them highly available for functionalization and as a result especially interesting for biomedical applications. Starting today, such conjugates are available commercially for the first time.

Sep 15th, 2011

Nanoindentation: Measuring in the sub-nanometer range

nanoindentationNanoindentation is derived from the classical hardness test but is carried out on a much smaller scale. It can be used to determine the hardness of thin layers as well as material properties such as elasticity, stiffness, plasticity, and tensile strength, or fracture toughness of small objects and microsystems in fields such as biotechnology. These measurements involve applying a small force to a sample using a sharp probe and measuring the resultant penetration depth. The measured value is used to calculate the contact area and hence the particular property of the sample material. Both the method of force application and the geometry of the indentation tip can be adjusted to suit the particular application.

Jun 29th, 2011

Monitoring morphological changes during electrodeposition of material with AFM

AFM_imagingThe copper Damascene electrodeposition is a key fabrication process, currently used in state-of-the-art, multilevel copper metallization of microelectronic interconnects that range from transistor to circuit board length scale. This strongly technology-driven application serves as a key motivator for applied and fundamental mechanistic studies that can spur further development and optimization of the copper electrodeposition process. This report effectively demonstrates the ability of the FlexAFM to monitor morphological changes during electrodeposition of material on an electrode surface. In the data shown here, copper was deposited on a flame annealed gold surface. The deposition process was shown to be fully reversible: At low potentials copper was deposited and at higher potentials it was dissolved again. Deposition and dissolution took place very rapidly, within one AFM scan line.

Feb 16th, 2011