Proteins are very specific about which other proteins or biochemicals they will interact with and therefore are of great use for biosensing applications. For instance, if a malignant cancer develops in the human body, the cancer cells produce certain types of proteins. Identifying such proteins enables early detection of cancer. One of the goals of nanobiotechnology is to develop protein chips that are sensitively responsive to a very tiny amount of specific proteins in order to enable such early stage diagnosis. For example, a protein that is known to bind to a protein produced by a cancer cell could be attached to a biochip. If this particular cancer cell protein were present in a sample passed over the chip, it would bind to the protein on the chip, causing a detectable change in the electrical signal passing through the chip. This change in the electrical signal would be registered by the device, confirming the presence of the protein in the sample. While this sounds very promising for the future of diagnostic systems, with the promise of protein chips capable of single-molecule resolution, the controlled assembly of proteins into bioactive nanostructures still is a key challenge in nanobiotechnology. Researchers in Germany took a further step towards this goal by developing a native protein nanolithography technique that allows for the nanostructured assembly of even fragile proteins.
Most of today's rocket engines rely on chemical propulsion. All current spacecraft use some form of chemical rocket for launch and most use them for attitude control as well (the control of the angular position and rotation of the spacecraft, either relative to the object that it is orbiting, or relative to the celestial sphere). Real rocket scientists though are actively researching new forms of space propulsion systems. One heavily researched area is electric propulsion (EP) that includes field emission electric propulsion (FEEP), colloid thrusters and other versions of field emission thrusters (FETs). EP systems significantly reduce the required propellant mass compared to conventional chemical rockets, allowing to increase the payload capacity or decrease the launch mass. EP has been successfully demonstrated as primary propulsion systems for NASA's Deep Space 1, Japan's HAYABUSA, and ESA's SMART11 missions. A new EP concept proposes to utilize electrostatically charged and accelerated nanoparticles as propellant. Millions of micron-sized nanoparticle thrusters would fit on one square centimeter, allowing the fabrication of highly scaleable thruster arrays.
A few years ago it was discovered that the process of thermal inkjet printing can be applied to fabricate hard tissue scaffolds (such as bones) and, just recently, soft tissue with liquid biomaterials. Research is also underway to use inkjet printing for the fabrication of organic semiconductors, which, because of their low stability, will be targeted at one-time-only applications such as water purity testers. Compared to the research done with respect to organic materials, inkjet printing of inorganic materials for the formation of active devices is relatively rare. To date, only a handful of inorganic materials have been inkjet printed, primarily because of the difficulty in preparing inkjet-printable precursors. Current methods for the production of functional inorganic electronic devices are quite expensive because they require the sequential deposition, patterning, and etching of selected semiconducting, conducting, and insulating materials, involving multiple photolithography and vacuum-deposition processes. Now though, researchers have come up with a process for printable inorganic semiconductors, opening a route to the fabrication of high-performance and ultra low-cost electronics such as transparent electronics and thin film solar cells.
Geneticists regularly use viruses as vectors to introduce genes into cells that they are studying. Viruses are also the most common carrier vehicles in gene therapy. Having been genetically altered to carry normal human DNA, they deliver the therapeutic genes to the patient's target cells. These viruses infect cells, deposit their DNA payloads, and take over the cells' machinery to produce the desirable proteins. Current trends in nanotechnology promise to take virus technology into an entirely new direction. From the viewpoint of a materials scientist, viruses can be regarded as organic nanoparticles. Their surface carries specific tools designed to cross the barriers of their host cells. The size and shape of viruses, and the number and nature of the functional groups on their surface, is precisely defined. As such, viruses are commonly used in materials science as scaffolds for covalently linked surface modifications. The powerful techniques developed by life sciences are becoming the basis of engineering approaches towards nanomaterials, opening a wide range of applications far beyond biology and medicine.
Piezoelectricity is a coupling between a material's mechanical and electrical behavior. When a piezoelectric material is squeezed, twisted, or bent, electric charges collect on its surfaces. Conversely, when a piezoelectric material is subjected to a voltage drop, it mechanically deforms. Many crystalline materials exhibit piezoelectric behavior and when such a crystal is mechanically deformed, the positive- and negative-charge centers are displaced with respect to each other. So while the overall crystal remains electrically neutral, the difference in charge center displacements results in an electric polarization within the crystal. Electric polarization resulting from mechanical deformation is perceived as piezoelectricity. This phenomenon was discovered by the brothers Pierre and Jacques Curie in 1880 and the word is derived from the Greek piezein, which means to squeeze or press. The piezoelectric effect finds useful applications such as the production and detection of sound, generation of high voltages, electronic frequency generation, microbalance, and ultra fine focusing of optical assemblies. For instance, types of piezoelectric motor include the well-known traveling-wave motor used for auto-focus in reflex cameras. A new research field, nanopiezotronics refers to generation of electrical energy at the nanometer scale via mechanical stress to the nanopiezotronic device. For example, bending of a zinc oxide nanowire transforms that mechanical energy into electrical energy. This new approach has the potential of converting biological mechanical energy, acoustic/ultrasonic vibration energy, and biofluid hydraulic energy into electricity, demonstrating a new pathway for self-powering of wireless nanodevices and nanosystems.
Since their discovery in the early 1990s, carbon nanotubes (CNTs) and carbon nanofibers (CNFs) have been used in a wide variety of applications. They have become indispensable in nanosciences and nanotechnology. However, because their production on an industrial scale remains expensive, their commercial use in such areas as catalysis has remained unthinkable. Current production processes including preparation of the support, normally silica or alumina, and impregnation with catalytically active metal for hydrocarbon decomposition, are not suitable for mass production. Researchers in Germany now report the fabrication of carbon nanotubes and carbon nanofibers on Mount Etna lavas used both as support and as catalyst, the first step for industrial production without preparation of support and its wet-chemical treatment. Such fabrication of CNTs/CNFs on naturally occurring minerals without synthetically prepared catalyst could pave the way for further exploitation of the superior properties of tailored nanostructured carbon for large-scale applications, such as catalysis and water purification by adsorption.
The earliest forgings, appearing around 1600 BC, were crudely hammered ornaments from naturally occurring free metals. The latest, most state-of-the-art forging techniques use micron-sized hammers to forge nanometer-sized metal shapes to be used as components in nanotechnology and microtechnology systems. New research demonstrates the possibilities of nanoforging - applying conventional metal shaping techniques to nano objects. In recent years, nanoscale fabrication has developed considerably, but the fabrication of free-standing nanosize components is still a great challenge. The ability to produce high-strength metallic components with characteristic dimensions of nanometers by nanoforging opens up new possibilities to eventually produce complex microsystems by assembling free-standing nanoscopic components. At these sizes they are of the same dimensions as micro-organisms and therefore sufficiently small even to travel through the human body.
Nanoelectronics devices often are made by integrating dissimilar classes of semiconductors and various other disparate materials into one heterogeneous single system. The two primary modes of combining these materials - mechanical bonding and epitaxial growth processes - place stringent requirements on the ultimate scale or constituent materials of circuits. With mechanical bonding, there is a limited ability to scale to large areas (i.e., larger than the wafers) or to more than a few stacking layers; incompatibility with unusual materials (such as nanostructured materials) and/or low-temperature materials and substrates; challenging fabrication and alignment for the through-wafer electrical interconnects; demanding requirements for planar bonding surfaces; and bowing and cracking that can occur from mechanical strains generated by differential thermal expansion and contraction of disparate materials. Epitaxy avoids some of these problems but places severe restrictions on the quality and type of materials that can be grown. Using a process akin to the printing press, researchers have managed to bypass the need for epitaxial growth or wafer bonding to integrate wide ranging classes of dissimilar semiconducting nanomaterials onto substrates for the purpose of constructing heterogeneous, three dimensional electronics.