In proteomics research, the study of the structure and function of proteins, chemical as well as physical methods are used to detect proteins. Physical methods are mostly applied after chromatography. They are either based on spectroscopy like light absorption at certain wavelengths or mass determination of peptides and their fragments with mass spectrometry. Chemical methods are used after two-dimensional electrophoresis and employ staining with organic dyes, metal chelates, fluorescent dyes, complexing with silver, or pre-labeling with fluorophores. What these various methods have in common is that they are not very fast, can be expensive, sometimes don't offer the sensitivity required, and are not always easy to handle. Since protein detection can be a powerful tool for diagnosing, prognosing, and monitoring cancers and other medical conditions, researchers are working towards developing detection platforms that can multiple specific molecules from the complex mixture present in serum, and is rapid, sensitive, and simple to administer. Researchers now have demonstrated a simple and rapid way of detecting proteins of interest using nanoparticles. This single step reaction starts with nanoparticle-antibody conjugates that form large aggregates if the intended protein molecules are present in the solution. The large aggregates can be characterized individually by laser scattering and fluorescence.
The most common type of modern transistor, and the type of transistor used in integrated circuits, is called a field-effect transistor (FET). The FET is so named because it relies on an electric field to control the shape and hence the conductivity of a 'channel' (the charge carrier) in a semiconductor material. This field causes a second electrical current to flow across the semiconductor, identical to the first weak signal, but stronger. Since the invention of the first transistor in 1947, the vast majority of electronic devices have been based on inorganic semiconductors, which in most cases has been silicon. Due to the demand for lightweight, flexible opto-electronic devices such as displays, solar cells and lasers, organic materials have become an important new class of semiconductor as they combine the virtues of plastics, which can be easily shaped, with those of semiconductors which are the basis of all microelectronics. Organic field-effect transistors (OFETs) have been mainly based on two types of semiconductors: conjugated polymers and small conjugated molecules. A recent review, published in Chemical Society Reviews, provides a general introduction about the current standing in the area of OFETs focusing on the new processable small molecules that have been recently reported for their use as organic semiconductors.
The newly created U.S. Nanotechnology Protection Agency (NPA) announced today, April 1, 2008, that, effective immediately, all laboratories and production facilities for molecular assemblers (commonly called nanobots) need a special license and have to follow strict guidelines in all research and production facilities that deal with nanoassemblers. At the same time, the NPA declared gray goo a hazardous substance. While the NPA regulations will have an immediate economic impact on many nanotechnology companies, most have been preparing for this dreaded day. However, public and media reactions seem to indicate that the public and many organizations were taken completely by surprise.
You probably have seen quite a number of research reports on the amazing climbing abilities of geckos. Here at Nanowerk, we ran several Spotlights on this topic, for instance on mimicking gecko toe structures to fabricate super-strong dry adhesives. One demonstration of so-called 'gecko tape' has already been used in building Stickybot, a quadruped robot capable of climbing smooth vertical surfaces, such as glass, acrylic and whiteboard. In addition to the animal kingdom, scientists have started looking at plants to identify biological climbing mechanisms that could be exploited for engineering applications. One obvious candidate is ivy, a climbing woody plant. Researchers now have found that ivy secretes nanoparticles which allow the plant to affix to a surface and play an important role in the plant's climbing capability. This ivy secretion mechanism may inspire new, 'green' methods for synthesizing nanoparticles biologically or new approaches to adhesion mechanisms for mechanical devices.
An Interagency Working Group on Manufacturing Research and Development established by the National Science and Technology Council has identified three technology areas as key research and development priorities for future manufacturing: Manufacturing for Hydrogen Technologies; Nanomanufacturing; and Intelligent and Integrated Manufacturing. The Working Group summarized their findings in a new report titled 'Manufacturing the Future.' Although this report is specific to the U.S., most of its general conclusions and recommendations apply to most other industrialized nations and their industrial nanotechnology efforts as well. Nanotechnology is viewed throughout the world as a critical driver of future economic growth and as a means to addressing some of humanity's most vexing challenges. Because of its broad range of prospective uses, nanotechnology has the potential to impact virtually every industry, from aerospace and energy to healthcare and agriculture. Nanomanufacturing integrates science and engineering knowledge and develops new processes and systems to assure quality nanomaterials, to control the assembly of molecular-scale elements, and to predictably incorporate nanoscale elements into nano-, micro-, and macroscale products utilizing new design methods and tools. Efforts in this area are directed toward enabling the mass production of reliable and affordable nanoscale materials, structures, devices, and systems. Nanomanufacturing includes the integration of ultra-miniaturized top-down processes and evolving bottom-up or self-assembly processes.
A key challenge in nano-optics is to bring light to and collect light from nano-scale systems. In conventional electronics, the interconnect between locally stored and radiated signals, for example radio broadcasts, is formed by antennas. For an antenna to work at the wavelength of light it needs to be greatly scaled down, to the nanoscale. Antennas play a key role in our modern wireless society. The electromagnetic waves sent and received by antennas are the messages that enable communication between electronics. Antennas with a wide variety of sizes make it possible for us receive radio broadcasts, watch television and talk to others on a mobile phone. For an effective communication, the antenna needs to direct signals towards their intended target and, vice versa, collect signals from a desired source. Now, researchers have shown that the concept of an antenna is equally well applied to direct the visible light sent out by a single molecule. For an antenna to work with visible light, it needs to be millions of times smaller than a conventional antenna. In this case, it is only 80 nanometer long. By placing the antenna near an individual molecule the light from that molecule is re-directed; the molecular message can be steered to a desired target, making efficient communication possible.
The success of the computer and communications industry is mainly due to the possibility of a large volume and low cost production output: silicon wafers containing myriad micro and nano structures are at the basis of Complementary Metal Oxide Semiconductor (CMOS) technology. A challenge is the realization of spatially ordered nanostructures in silicon that have many interesting applications like photonic crystals to mod the flow of light, chemical sensors, devices to alter the wetting of liquids on a surface, and as capacitors in high-frequency electronics used in mobile phones. The incorporation of such structures on existing silicon chips is greatly desired, and adapting conventional semiconductor nanofabrication to that end is widely pursued. Just a few days ago we wrote about the general aspects and challenges of silicon photonics and today we are taking a look at a specific fabrication challenge. The challenge for researchers is to to obtain photonic crystals with stop bands in the telecommunication wavelength regions, i.e.1330 nm and 1550 nm. To do that, the diameter of these pores must be smaller than 500 nm. The pore to pore distances, also referred to as pitch or interpore distance, must be well below 1 micrometer. Furthermore the depth to diameter aspect ratio of the pores must be as high as possible to obtain photonic crystals with large enough volumes. Researchers in The Netherlands now have demonstrated a method to etch arrays of nanopores in silicon with record depth-to-diameter ratios. These structures are suitable for nanophotonics and were made completely with CMOS compatible technologies, making integration of photonic structures in silicon chips feasible.
Polymethylmethacrylate (PMMA), a clear plastic, is a pretty versatile material. Plexiglas windows are made from PMMA. Acrylic paints contain PMMA. It also remains one of the most enduring materials in orthopedic surgery where it has a central role in the success of total joint replacement. Being part of a group of medical materials called 'bone cement', its use includes the fixation of biomaterials such as artificial joints to bone, the filling of bone defects and, also, as a drug-delivery system. Beginning in the 1970s, many successful results have been reported for total hip replacement using PMMA cement; however, failures of fixation have also occurred. The fixation strength of PMMA cement to bone is mainly dependent on mechanical interlocking, but it is known that a fibrous tissue layer intervenes between cement and bone - PMMA cement never bonds directly to the bone. One of the problems associated with the conventional types of bone cement used is their unsatisfactory mechanical and exothermic reaction properties. Other problems with PMMA cement include the biological response, leakage of the monomer of methylmethacrylate and a high curing temperature, which can damage cell activity. Ideally, a bone cement material must functionally match the mechanical behavior of the tissue to be replaced, it must be able to form a stable interface with the surrounding natural tissue and be effective in guided tissue regenerative procedures, it should be easy to handle, biologically compatible, non-supporting of microbial growth, and non-allergenic. A novel nanocomposite of carbon-nanotube-reinforced PMMA/HA is a demonstration of how nanomaterials will play an increasing role in the synthesis of next-generation biomedical applications.