Damaged articular cartilages, like the ones found in the knee joint, ordinarily demonstrate a very limited capability for self-healing. Functional restoration of diseased or damaged articular cartilage is a major clinical challenge. There have been a number of successful approaches to tissue engineered cartilage, including the use of natural and synthetic biomaterial scaffolds. Although recent progress has been made in engineering cartilage of various shapes and sizes for cosmetic purposes, current treatments for cartilage repair are less than satisfactory, and rarely restore full function or return the tissue to its native state. Researchers have now developed nanofibrous hollow microspheres self-assembled from star-shaped biodegradable polymers as an injectable cell carrier. When the spheres are injected with cells into wounds, these spheres biodegrade, but the cells live on to form new tissue.
Glues adhere to solid materials via a multitude of fundamental physical or chemical interactions. Either chemical reaction times or solvent evaporation rates determine the point in time, when this interaction sets in and fixes the object to be glued. Electric potential has been used to attract polymers continuously to an electrode surface and to toggle molecules between states for a molecular switch. If you wanted to create electric glue, you would need to be able to control the interaction of a polymer and an electrode surface reversibly, thus creating a nanoscale system with electrochemically controlled adhesion. A research team now describes how Coulomb forces between polymers and surfaces may be measured, controlled, and manipulated.
Heparin is widely used as an anti-coagulant to prevent the formation of blood clots. This naturally occurring biological molecule is commonly used during surgery for blood thinning. At the end of surgery, heparin has to be removed in order to allow the blood to clot again - this is currently done using a protein called protamine, the only clinically approved heparin binder. Unfortunately, protamine can cause severe allergic reactions in a number of patients. Researchers at the University of York have now developed a synthetic molecule which is capable of binding heparin just as effectively as protamine. The team's approach may eventually be useful for developing protamine replacements.
There is a general perception that nanotechnologies will have a significant impact on developing 'green' and 'clean' technologies with considerable environmental benefits. However, the environmental footprint created by today's nanomanufacturing technologies are conflicting with the general perception that nanotechnology environmentally benign. It actually appears that certain nanomaterial production technologies are quite dirty and also have a considerable energy footprint. Determining the full environmental impact of nanomaterials requires a full life cycle assessment. A recent paper takes a look at the material and energy intensity of fullerene production. It finds that the embodied energy of all fullerenes are an order of magnitude higher than most common chemicals.
The extremely high electron mobility of graphene - under ideal conditions electrons move through it with roughly 100 times the mobility they have in silicon - combined with its superior strength and the fact that it is nearly transparent (2.3 % of light is absorbed; 97.7 % transmitted), make it an ideal candidate for photovoltaic applications. Recent research suggests, though, that doping is a necessity to harvest the full potential of graphene. The challenge then for researchers is to find suitable fabrication techniques for high-quality graphene flakes that exhibit high charge mobilities. Researchers now present a chemical approach towards non-covalently functionalized graphene, which is generated from vastly available and low-priced natural graphite.
Ink-jet printing of metal nanoparticles for conductive metal patterns has attracted great interest as an alternative to expensive fabrication techniques like vapor deposition. The bulk of the research in this area focuses on printing metal nanoparticle suspensions (metallic ink) for metallization. Printing conductive features by metallic nanoparticle inks must be followed by an additional step of sintering, usually achieved by heating to elevated temperatures. In this step, the nanoparticles composing the pattern will coalesce to form a continuous electrical contact. In new work, researchers have now demonstrated a new conductive ink that won't require a post printing sintering step. It is achieved by the addition of a latent sintering agent that gets into action after the printing step. Once the solvent evaporates, the sintering agent concentration increases, leading to the spontaneous sintering of the nanoparticles.
Engineered nanomaterials present regulators with a conundrum - there is a gut feeling that these materials present a new regulatory challenge, yet the nature and resolution of this challenge remains elusive. But as the debate over the regulation of nanomaterials continues, there are worrying signs that discussions are being driven less by the science of how these materials might cause harm, and more by the politics of confusion and uncertainty. Yet the more we learn about how materials interact with biology, the less clear it becomes where the boundaries of this class of materials called "nanomaterials" lie, or even whether this is a legitimate class of material at all from a regulatory perspective.
One of the problems in modern separation science and technology is the challenge of separating gaseous mixtures that consist of very similar particles, for example, hydrogen isotope mixtures; mixtures of noble gases; etc. The problem arises because small particles such as hydrogen isotopes share similar size and shape (only their molecular mass is different). While this problem can be technically solved, currently available separation methods such as thermal diffusion, cryogenic distillation, and centrifugation, tend to be time and energy intensive. New theoretical work now shows that narrow carbon nanotubes (CNTs) seem to be an attractive alternative. By using CNTs as nanoporous molecular sieves, the separation of parahydrogen molecules from mixtures of classical particles at cryogenic temperatures seems to be possible.