Showing Spotlights 97 - 104 of 538 in category All (newest first):
Researchers exploited for the first time cellular self-recognition process for targeting glioblastoma cells with boron nitride nanotubes (BNNTs), a biocompatible, yet inorganic, nanomaterial.
The team loaded the BNNTs with doxorubicin, a powerful chemotherapy drug, and then functionalized them with glioblastoma cell membranes This targeting approach benefits from the ability of cancer cells to recognize each other due to similarities present on their membrane that make them different from healthy cells.
May 11th, 2020
Deep brain stimulation (DBS) is an effective treatment for many neurological disorders, but despite its widespread utilization the underlying mechanisms and downstream effects of DBS remain poorly understood. One major issue to understand the therapeutic mechanism of DBS is to map the wide variety of brain responses at both the local and global levels. Researchers have developed a highly MRI-compatible graphene fiber electrode that enables full activation pattern mapping by functional magnetic resonance imaging under DBS without the occurence of artifacts resulting from magnetic field interference.
Apr 20th, 2020
Recent developments in hydrogel chemistries, reinforcement approaches, and crosslinking methods have expanded the applications of 3D bioprinting to pharmaceutics, regenerative medicine, and biomedical devices. A multitude of 3D bioprinting techniques have been developed, but among these different approaches, extrusion-based 3D bioprinting has become a popular technique as it is easy to optimize and all its constituents are economical in price. A recent review elucidates the nuances of 3D bioprinting in a step-by-step guideline format, from its basics to more advanced levels.
Apr 10th, 2020
Nanotechnology offers many benefits that can be leveraged to increase the potency of vaccine formulations. For anticancer vaccination, antigenic material can be collected directly from a patient's resected tumor, formulated into a biomimetic nanoparticle, and then administered back into the patient to promote tumor-specific immunity. For antibacterial vaccination, strain-specific virulence factors or membrane can be immobilized onto nanoparticle substrates, and the resulting complexes can be used to vaccinate patients with an identified risk against the associated pathogen.
Apr 3rd, 2020
Biofabrication is a revolutionizing toolkit for regenerative medicine that allows cells and other biomaterials to be precisely combined and patterned into three-dimensional (3D) constructs through automated, cell-friendly fabrication methods. With rapid advanced in 3D-printing hardware on one hand and bioink materials on the other, biofabrication techniques have gained significant momentum and provide a powerful approach to tackle major hurdles in the generation of engineered living tissues. While 3D bioprinting is still in its early stages, the remarkable leap it has made in recent years points to the eventual reality of lab-grown, functional organs.
Mar 25th, 2020
New types of magnetic nanostructures have interesting properties that enhance novel medical applications in diagnosis and allow the exploration of new therapeutic techniques. In a new paper, researchers review promising new nanomaterials that can be used in cancer diagnosis and treatment, namely as magnetic resonance imaging (MRI) contrast agents. One especially interesting advance involves exotic spin configurations, like a vortex state in nanodiscs, where magnetic moments arrange into a curly geometry.
Feb 6th, 2020
Proteins present in human plasma mirror a person's physiology and the ability to rapidly profile the plasma proteome holds the promise of a revolution in point-of-care disease diagnosis and therapeutic monitoring. New research findings suggest that levitation patterns of human plasma proteins using a magnetic levitation technique may provide useful information about the health spectrum of individual donors. The study reveals that optical images of magnetically levitated plasma proteins carry important information about the health spectrum of plasma donors.
Feb 3rd, 2020
The density of proteins in solution is an important fundamental biophysical quantity that has not been accurately measured yet. This has led to extensive debate in the literature regarding the precise density value of proteins. This rough density metric can often lead to inaccurate estimates on the other physicochemical and composite protein features, especially after their interactions with other materials such as nanoparticles. Researchers have now demonstrated a new technique using superparamagnetic iron oxide nanoparticles for magnetic levitation, which promises a more precisely measurement of the density of proteins in solution.
Jan 13th, 2020