Showing Spotlights 89 - 96 of 538 in category All (newest first):
The physicochemical properties of nanoparticles alone cannot predict the fate of nanoparticles in biological systems. Current evidence suggests that the formation of a corona on the nanoparticle surface is the most important parameter that controls nanoparticle toxicity. Scientists now showed that protein corona modulates internalisation and cytotoxicity of nanodiamonds in non-phagocytic and phagocytic cells. Specifically, they found that corona made of bovine serum albumin (BSA), which represents the most abundant protein in blood plasma, reduced nanodiamond agglomeration.
Sep 4th, 2020
The only options to control and deal with the spread of the Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2) are fast, cheap, reliable, and portable means of diagnosing COVID-19 infection (the name of disease caused by SARS-CoV-2); therapeutics to treat the infected; and vaccines to rapidly build up immunization of large parts of the global population. The current crisis demands an urgent analysis of all the available nanotechnology tools. While nanomedicine strategies are in use for the design of the vaccine carriers, there are not enough other nanotechnology approaches being explored to tackle the current outbreak.
Jun 26th, 2020
Vertical semiconductor nanowire arrays are a promising material for retinal prostheses, which could help restore the eyesight of people suffering from severe retinal diseases. These nanowires could also be used to fabricate bio-inspired photoreceptors and lightweight, highly efficient photovoltaics. In new work, scientists present theoretical and experimental studies on the microscopic optical behavior of highly dense and randomly distributed nanowire arrays embedded in a transparent polymer.
Jun 18th, 2020
New research demonstrates the integration of synthetic biology with electronic circuitry through engineered population dynamics that regulate the accumulation of charged metabolites. The resulting sensor devices can detect changes in bacterial population in response to the presence of chemicals, light or pH. Connecting bacterial gene expression to electrodes is an appealing approach to interface genetic circuits with microelectronics for multiple applications. In this work, researchers engineered bacterial circuits capable of controlling the conductivity of the media via cell growth and death. Therefore, the electronic output is controlled by a killing gene.
May 26th, 2020
Miniaturized needle-like carriers in high aspect ratio structures are a novel class of implantable electronic devices. They are used to deliver tiny sensors and stimulation tools inside the body via minimally invasive injection or insertion into a specific area of an organ. A recent review summarizes the latest developments in materials, designs, and manufacturing techniques in the field of injectable biomedical devices, highlighting unique applications and demonstrations of viable clinical tools that were applied in various internal organs.
May 19th, 2020
Hepatocellular carcinoma (HCC) is is the most common type of primary liver cancer and one of the most aggressive and hyper-vascularized forms of cancer. Many current chemotherapeutics fail to achieve the effective therapeutic index in the solid tumours due to poor drug penetration, poor bioavailability, non-specificity and drug resistance - a challenging aspect in this field. In search of new modalities, researchers have developed multifunctional polymeric nanoparticles against HCC. These biocompatible multifunctional polymeric nanoparticles hold trimodal affinity towards targeting microtubules, tyrosine kinases, and high-sensitivity imaging system quantum dots.
May 14th, 2020
Breath is one of the main sources of human health parameters that can be used for predicting the state of internal organs. Exhaled breath composition is very complex and the existence of disease marker molecules can be as low as one part per million. That means that using breath for health monitoring purposes requires highly sensitive tools with a recognition ability down to single molecules. Researchers developed a method for fast, on-site and still accurate breath analysis that does not need special preparation of breath samples. The method is based on an electronic nose platform that uses a set of single-walled carbon nanotube sensors deposited on flexible substrates and modified by different semiconducting organic molecules.
May 13th, 2020
In the absence of vaccines, many scientists argue that the best approach to control the spread of the Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2) would be fast, cheap, reliable, and portable means of diagnosing COVID-19 infection. In particular, the identification of patients with the highest risk of COVID-19 mortality (i.e. those with co-morbidities such as cardiovascular disorders or massive alveolar damage and progressive respiratory failure) could significantly improve the capacity of healthcare providers to take early action and minimize the possibility of overwhelming care centers, which in turn would save many lives.
May 12th, 2020