Showing Spotlights 9 - 16 of 439 in category Bionanotechnology, Nanomedicine (newest first):
Researchers have for the first time proposed a novel tumor treatment strategy for microwave dynamic therapy to effectively treat cancers. This technique can promote the efficacy of dynamic treatment of deep tumors in clinical research and could have a broad range of applications. The team found that liquid metal supernanoparticles can generate reactive oxygen species (ROS) under microwave irradiation. That makes them suitable as microwave sensitizers for revolutionizing the ROS generation techniques.
Jul 25th, 2019
Turmeric has a long history of usage in traditional medicine in India and China. Ancient Indians have known the medicinal properties of turmeric - i.e. curcumin - for several millennia. Researchers have now investigated the antibacterial effects of curcumin loaded into halloysite nanotubes and found that this nanoformulation drastically increased the life expectancy of nematodes infected by pathogenic bacteria. The most interesting finding here is the selective antimicrobial action of curcumin, which suppressed one bacterial species, while demonstrating no adverse effect on another.
Jul 15th, 2019
When nanoparticles enter the blood stream or other biological fluids, they are quickly surrounded by a layer of proteins. This so-called protein corona on the nanoparticles hinders interactions between the targeting ligands on the nanoparticles and their binding partners on the cells' surface. Different individuals may have a personalized protein corona owing to their distinct type, severity and period of disease, heterogeneity, individual genetic variations and environmental factors. By combining the concepts of disease-specific protein corona and sensor array technology, researchers now have created a label-free platform for the early detection and identification of diseases.
Jun 17th, 2019
A critical challenge in gene therapy is the safe and effective delivery of genetic materials across cell membranes into target cells. Although viral systems have been the most effective method for delivering genetic matter into cells, they pose significant safety problems. Demonstrating a novel alternative delivery vector, researchers have developed a facile one-pot strategy to encapsulate plasmid DNA into nanoscale metal-organic frameworks (MOFs) and a MOF-polymer system Experiments showed that pDNA molecules could be well distributed throughout the MOF nanostructures and benefited from effective protection against the enzymatic degradation.
Jun 13th, 2019
The use of TiO2 nanoparticles activated by light and ultrasound has been studied extensively for cancer treatments. For the first time, researchers have shown the nanoparticles can be effectively activated by microwaves for cancer cell destruction - potentially opening new doors for patients fighting cancer. They propose the use of microwaves and TiO2 nanoparticles to induce the production of reactive oxygen species (ROS), which has the potential to be a safer, more effective modality for cancer treatment.
May 30th, 2019
New work on self-propelled biohybrid microrobots has been inspired by recent developments of biohybrid cyborgs that integrate self-propelling bacteria with functionalized synthetic nanostructures to transport materials. Taking inspiration from the science fiction concept of a cybernetic organism, or cyborg, researchers developed a self-propelled biohybrid microrobot, named rotibot, employing the marine microorganism rotifer as their engine.
Apr 3rd, 2019
Alpha-synuclein is a protein whose function in the healthy brain is currently unknown. It is of great interest to Parkinson's researchers because it is a major constituent of Lewy bodies, protein clumps that are the pathological hallmark of Parkinson's disease (PD). Scientists believe that the self-assembly of alpha-synuclein into oligomers and fibrils is linked to progress and pathogenesis of the disease. A new study suggest that important characteristics of the fibrillation process, such as surface charge and surface functional group, should be considered in the development of nanotechnology-based therapeutic approaches.
Mar 19th, 2019
Nanoparticles that mimic the complexity and function of natural enzymes can act as effective peroxidase to catalyse for the oxidization of 3,3,5,5-tetramethylbenzidine (TMB), generating an oxidised blue-coloured product. For the first time scientists found that when the surface of gold nanoparticle (AuNPs) is coated with casein, the intrinsic peroxidase-mimicking activity of AuNPs is suppressed strongly, i.e. by up to 77.1%, due to the surface shielding effects.
Dec 6th, 2018