Showing Spotlights 33 - 40 of 427 in category Bionanotechnology, Nanomedicine (newest first):
The crucial roles of the physicochemical properties of cell culture substrates on function and behavior of a wide range of the cells are becoming well-studied in the current literature, using experimental approaches. However, development of in silico approaches for prediction of cell responses to the physicochemical properties of substrates is still in its infancy. In new work, an international team of researchers has developed a unifying computational framework to create a multi-component virtual cell model to probe cell function/behavior in silico.
Nov 1st, 2017
Researchers explore cellular uptake, endocytic pathways, and intracellular dynamics of nanoparticles in HeLa cells, both in absence and presence of biomolecular corona from human plasma. They find that the biomolecular corona could act as a personalized 'endogenous trigger' affecting off-target interactions and controlling the indication for disease of clinically approved formulations. Mechanistic investigations of the biomolecular corona could contribute to a better understanding of the poor success of targeted liposomal technology.
Oct 23rd, 2017
Notwithstanding the progress neuroscientists have made in understanding the microscale function of single neurons and the macroscale activity of the human brain - a comprehensive understanding of the brain still remains an elusive goal. Here we review the basic concepts associated with neuroscience and the current journey of nanotechnology towards the study of neuron function by addressing various concerns on the significant role of nanomaterials in neuroscience and by describing the future applications of this emerging technology.
Oct 18th, 2017
Nanotechnology materials are going to open new realms of possibility for flexible and stretchable monitoring gadgets that are wearable directly on the skin. Here we look at the latest developments in a class of electronic devices, commonly referred to as electronic skin, epidermal electronics, or electronic tattoos, from the materials, devices, and medical applications perspectives. While such devices can also be used for prosthetics and rehabilitation, optogenetics, and human-machine interfaces, this review focuses on the properties of the materials that enable skin-mounted sensors for use as diagnostic tools in the medical field.
Sep 26th, 2017
In order to fully exploit the potential of neural interfaces, the forthcoming generation of devices is expected to simultaneously offer multiple functionalities, including recording and stimulation of electrical activity, recognition of neurotransmitters, neuromodulators and other neurologically relevant biomolecules, as well as the capability for controlled drug delivery. Graphene and other 2D materials possess an array of properties (flexibility, electrical mobility, large surface area available for interaction with the neuronal components and amenable to surface modifications) that can enable enhanced functional capabilities for neural interfaces.
Sep 22nd, 2017
Nanostructured systems have the potential to revolutionize both preventive and therapeutic approaches for treating cardiovascular disease. Given the unique physical and chemical properties of nanostructured systems, nanoscience and nanotechnology have recently demonstrated the potential to overcome many of the limitations of cardiovascular medicine through the development of new pharmaceuticals, imaging reagents and modalities, and biomedical devices. A recent review offers an outline of critical issues and emerging developments in cardiac nanotechnology.
Sep 14th, 2017
In recent years, researchers working in neurobiology have been intrigued by the idea of microtubule-stabilizing drugs as a therapy to augment nerve regeneration. In new work, scientists show that a better idea is to increase the amount of the dynamic parts of the microtubules. They do this by reducing the levels of fidgetin, a protein that normally exists in nerves to keep the dynamic parts of microtubules from elongating too much.
Sep 8th, 2017
The implantation of orthopaedic devices is associated with a high risk of post-operative complications that increases substantially with each revision surgery. Researchers now have proposed a two-pronged strategy to address this outstanding clinical problem by combatting infections and providing bioactivity for titanium implants. Their nanostructured surfaces simultaneously are highly antimicrobial as well as bioactive - the goal of combining both functions without inducing cytotoxicity has thus far proved elusive.
Sep 4th, 2017